Metabolic Aspects of Alcoholism

  • Charles S. Lieber

Table of contents

  1. Front Matter
    Pages i-ix
  2. C. S. Lieber
    Pages 1-29
  3. C. S. Lieber, L. M. DeCarli
    Pages 31-79
  4. E. Baraona, J. Lindenbaum
    Pages 81-116
  5. R. J. Bing, H. Tillmanns
    Pages 117-134
  6. P. D. Saville
    Pages 135-147
  7. E. P. Noble, S. Tewari
    Pages 149-185
  8. S. A. Geller, E. Rubin
    Pages 187-213
  9. G. G. Gordon, A. L. Southren
    Pages 249-302
  10. Back Matter
    Pages 303-308

About this book

Introduction

In the first annual report on Alcohol and. Health to Congress (December, 1971), the then HEW Secretary Elliot L. Richardson called alcohol 'the most abused drug in the United States'. The report revealed that nine million Americans are alcohol abusers and that alcoholic individuals represent almost 10 % of the nation's work force. With spreading alcoholism, the incidence of physical damage due to alcohol has greatly increased. A question which is often raised is 'in which way does an alcoholic differ from a non-alcoholic?' Inquiries have focused on psychological make-up, behavioural differences and socioeconomic factors. More recently, however, physical differences have been delineated. Prior to the development of various disease entities, chronic ethanol exposure results in profound biochemical and morphological changes. Consequently an alcoholic does not respond normally to alcohol, or other drugs or even other toxic agents. Some of these persistent biochemical and morphological changes are the consequences of the injurious effects of ethanol, whereas others may represent the possible adaptive responses to the profound changes in intermediary metabolism which are a direct and im­ mediate consequence of the oxidation of ethanol itself. Differentiation between the effects of ethanol directly linked to its oxidation, and the adaptive and injurious effects of ethanol are not simple, and overlap is common. In general, however, metabolic effects are associated with the presence of relatively low ethanol concentrations, whereas injurious effects occur with high ethanol concentrations and/or after prolonged intake. High ethanol con­ centrations also produce so-called pharmacological effects.

Keywords

alcohol alcoholism behavior blood bone bone marrow brain drug drugs ethanol health heart liver metabolism smooth muscle

Editors and affiliations

  • Charles S. Lieber
    • 1
    • 2
  1. 1.Section of Liver Disease, Nutrition and AlcoholismVeterans Administration HospitalNew YorkUSA
  2. 2.Mount Sinai School of Medicine (CUNY)New YorkUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-94-011-6153-4
  • Copyright Information Springer Science+Business Media B.V. 1977
  • Publisher Name Springer, Dordrecht
  • eBook Packages Springer Book Archive
  • Print ISBN 978-94-011-6155-8
  • Online ISBN 978-94-011-6153-4
  • About this book
Industry Sectors
Biotechnology
Pharma