Liver Growth and Repair

  • Editors
  • Alastair Strain
  • Anne Mae Diehl

Table of contents

  1. Front Matter
    Pages i-xix
  2. Molecular and Cellular Analysis of Liver Growth

    1. Front Matter
      Pages 1-1
    2. Nancy L. R. Bucher, Stephen R. Farmer
      Pages 3-27
    3. William B. Coleman, Joe W. Grisham
      Pages 50-99
    4. Eric Santoni-Rugiu, Snorri S. Thorgeirsson
      Pages 100-142
    5. Bonnie Burgess-Beusse, Humberto E. Soriano, Gretchen J. Darlington
      Pages 143-162
    6. Kenji Fujiwara, Sumiko Nagoshi
      Pages 163-182
  3. Growth Factors

    1. Front Matter
      Pages 183-183
    2. William E. Russell, Robert S. Carver
      Pages 185-218
    3. Mikio Kan, Wallace L. McKeehan
      Pages 240-260
    4. Raymond N. DuBois, David Myers, R. Daniel Beauchamp
      Pages 261-282
    5. Giuliano Ramadori, Thomas Armbrust
      Pages 283-294
  4. Signaling Events

    1. Front Matter
      Pages 295-295
    2. J. K. Westwick, D. A. Brenner
      Pages 297-310
    3. Janeen H. Trembley, Betsy T. Kren, Clifford J. Steer
      Pages 311-365
    4. Jan B. Hoek, Emanuel Rubin
      Pages 366-401
  5. Biology of the Extracellular Matrix and Non-Parenchymal Cells

    1. Front Matter
      Pages 403-403
    2. Malcolm Lyon
      Pages 405-429

About this book

Introduction

Nelson Fausto The Greek myth of Prometheus with its picture of a vulture feasting on its chained victimhas traditionallyprovided a visualimageofliverregeneration. Itis apowerful and frightening representationbut ifone were to substitute the vulture by a surgeon and Prometheus by a patient laying on a properly prepared operating table, the outcomeoftheprocedurewould not differ significantlyfrom that describedbyGreek poets. Yet few of us who work in the field have stopped long enough to ask where this myth originated. Did the poet observe a case of liver regeneration in a human being? Was it brilliant intuition or perhaps, literally, just a 'gut feeling' of a poet looking for good rhymes that led to the prediction that livers grow when part of the tissueisremoved? Thisbookdoesnotattemptto solve these historical issues. Itdoes, instead, cover in detail some of the major modem themes of research on liver regen­ eration, injury and repair. As indicated in Dr. N. Bucher's chapter, the modem phase ofexperimental studies on liver regeneration started in 1931 with the publication by Higgins and Anderson of a method to perform a two-thirds resection of the liver of a rat. The technique described has 3 remarkable features: 1) it is highly reproducible, resulting in the removal of 68% of the liver, 2) it has minimal if any mortality, and 3) it consists only of blood vessel ligation and does not involve cutting through or wounding hepatic tissue.

Keywords

cells cyclin development endothelium genes transcription

Bibliographic information

  • DOI https://doi.org/10.1007/978-94-011-4932-7
  • Copyright Information Springer Science+Business Media Dordrecht 1998
  • Publisher Name Springer, Dordrecht
  • eBook Packages Springer Book Archive
  • Print ISBN 978-94-010-6069-1
  • Online ISBN 978-94-011-4932-7
  • About this book
Industry Sectors
Biotechnology
Pharma