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Technological and Medical Implications of Metabolic Control Analysis

  • Athel Cornish-Bowden
  • María Luz Cárdenas

Part of the NATO Science Series book series (ASHT, volume 74)

Table of contents

  1. Front Matter
    Pages i-xiv
  2. Provoking an Argument: Problems with Current Approaches to the Analysis of Biochemical Systems

    1. Front Matter
      Pages 1-1
    2. Douglas B. Kell, Pedro Mendes
      Pages 3-25
    3. Johann M. Rohwer, Brett G. Olivier, Jan-Hendrik S. Hofmeyr
      Pages 27-32
  3. Imposing Discipline: Manipulation of Organisms for Technological Ends

    1. Front Matter
      Pages 39-39
    2. James E. Bailey
      Pages 41-47
    3. Stefan Schuster, Thomas Dandekar, Klaus Mauch, Matthias Reuss, David Fell
      Pages 57-66
    4. Jacky L. Snoep, Coen C. van der Weijden, Heidi W. Andersen, Hans V. Westerhoff, Peter R. Jensen
      Pages 67-72
  4. Understanding Health and Disease: Why Organisms Behave as They Do

  5. Taking Aim: Use of Metabolic Models to Identify Drug Targets

    1. Front Matter
      Pages 147-147
    2. Barbara M. Bakker, Paul A. M. Michels, Michael C. Walsh, Fred R. Opperdoes, Hans V. Westerhoff
      Pages 157-164
    3. Athel Cornish-Bowden, Robert Eisenthal
      Pages 165-172
    4. Marta Cascante, Begoña Comin, Joan Boren, Badr Raïs, Josep J. Centelles, Joaquim Puigjaner et al.
      Pages 173-180
  6. Facing Reality: Not Just a Bag of Enymes

    1. Front Matter
      Pages 181-181
    2. Károly Liliom, Gábor Wágner, Ferenc Orosz, János Kovács, Judit Ovádi
      Pages 183-190
    3. Kevin M. Brindle, Peter M. Haggie
      Pages 191-198
    4. Natalie S. Cohen, Chia-Wei Cheung, Luisa Raijman
      Pages 199-206
    5. Juan C. Ferrer, Susanna Baqué, Josep M. Fernández-Novell, Mar García-Rocha, Joan J. Guinovart
      Pages 207-214
  7. Thinking About Metabolism: The Relationship Between Control and Regulation

    1. Front Matter
      Pages 233-233
    2. Hans V. Westerhoff, Bas Teusink, Femke Mensonides, Karin A. Reijenga, Eugenia Esgalhado, Boris N. Kholodenko et al.
      Pages 235-242
    3. Simon Thomas, David A. Fell
      Pages 259-266
    4. David A. Fell, Simon Thomas
      Pages 267-274
    5. Christoph Giersch
      Pages 283-288
    6. Jan-Hendrik S. Hofmeyr, Brett G. Olivier, Johann M. Rohwer
      Pages 299-308
    7. Enrique Meléndez-Hevia, Ruth Meléndez, Enric I. Canela
      Pages 319-326
  8. Taking Stock: Control Analysis in the Context of Metabolic Regulation

  9. Back Matter
    Pages 347-374

About this book

Introduction

Two decades have passed since the mechanisms of protein synthesis became well enough understood to permit the genetic modification oforganisms. An impressive amount of new knowledge has emerged from the new technology, but much ofthe promise of20years ago has notyet been fulfilled. In biotechnology, efforts to increase the yields of commercially valuable metabolites have been less successful than ex­ pected, and when they have succeeded it has often been as much from selective breeding as from new methods. The cell is more complicated than what is presented in the classical teaching of biochemistry, it contains more structure than was dreamed of 20 years ago, and the behaviour ofany systemofenzymes is more elaborate than can be explained in terms ofa single supposedly rate-limiting enzyme. Even if classical enzymology and meta­ bolism may have seemed rather unfashionable during the rise ofmolecular biology, they remain central to any modification ofthe metabolic behaviour oforganisms. As such modification is essential in much ofbiotechnology and drug development, bio­ technologists can only ignore these topics at their peril.

Keywords

behavior biochemistry biotechnology cell drug development enzymes metabolism

Editors and affiliations

  • Athel Cornish-Bowden
    • 1
  • María Luz Cárdenas
    • 1
  1. 1.Centre National de la Recherche ScientifiqueBioénergétique et Ingéniérie des ProtéinesMarseilleFrance

Bibliographic information

  • DOI https://doi.org/10.1007/978-94-011-4072-0
  • Copyright Information Springer Science+Business Media B.V. 2000
  • Publisher Name Springer, Dordrecht
  • eBook Packages Springer Book Archive
  • Print ISBN 978-0-7923-6189-3
  • Online ISBN 978-94-011-4072-0
  • Series Print ISSN 1388-6576
  • Buy this book on publisher's site
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