Technological and Medical Implications of Metabolic Control Analysis

  • Athel Cornish-Bowden
  • María Luz Cárdenas

Part of the NATO Science Series book series (ASHT, volume 74)

Table of contents

  1. Front Matter
    Pages i-xiv
  2. Provoking an Argument: Problems with Current Approaches to the Analysis of Biochemical Systems

    1. Front Matter
      Pages 1-1
    2. Douglas B. Kell, Pedro Mendes
      Pages 3-25
    3. Johann M. Rohwer, Brett G. Olivier, Jan-Hendrik S. Hofmeyr
      Pages 27-32
  3. Imposing Discipline: Manipulation of Organisms for Technological Ends

    1. Front Matter
      Pages 39-39
    2. James E. Bailey
      Pages 41-47
    3. Stefan Schuster, Thomas Dandekar, Klaus Mauch, Matthias Reuss, David Fell
      Pages 57-66
    4. Jacky L. Snoep, Coen C. van der Weijden, Heidi W. Andersen, Hans V. Westerhoff, Peter R. Jensen
      Pages 67-72
  4. Understanding Health and Disease: Why Organisms Behave as They Do

  5. Taking Aim: Use of Metabolic Models to Identify Drug Targets

    1. Front Matter
      Pages 147-147

About this book


Two decades have passed since the mechanisms of protein synthesis became well enough understood to permit the genetic modification oforganisms. An impressive amount of new knowledge has emerged from the new technology, but much ofthe promise of20years ago has notyet been fulfilled. In biotechnology, efforts to increase the yields of commercially valuable metabolites have been less successful than ex­ pected, and when they have succeeded it has often been as much from selective breeding as from new methods. The cell is more complicated than what is presented in the classical teaching of biochemistry, it contains more structure than was dreamed of 20 years ago, and the behaviour ofany systemofenzymes is more elaborate than can be explained in terms ofa single supposedly rate-limiting enzyme. Even if classical enzymology and meta­ bolism may have seemed rather unfashionable during the rise ofmolecular biology, they remain central to any modification ofthe metabolic behaviour oforganisms. As such modification is essential in much ofbiotechnology and drug development, bio­ technologists can only ignore these topics at their peril.


behavior biochemistry biotechnology cell drug development enzymes metabolism

Editors and affiliations

  • Athel Cornish-Bowden
    • 1
  • María Luz Cárdenas
    • 1
  1. 1.Centre National de la Recherche ScientifiqueBioénergétique et Ingéniérie des ProtéinesMarseilleFrance

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media B.V. 2000
  • Publisher Name Springer, Dordrecht
  • eBook Packages Springer Book Archive
  • Print ISBN 978-0-7923-6189-3
  • Online ISBN 978-94-011-4072-0
  • Series Print ISSN 1388-6576
  • About this book
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