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Organic Acids in Man

Analytical Chemistry, Biochemistry and Diagnosis of the Organic Acidurias

  • R. A. Chalmers
  • A. M. Lawson

Table of contents

  1. Front Matter
    Pages i-xiii
  2. Introduction

    1. R. A. Chalmers, A. M. Lawson
      Pages 1-8
  3. Methods

    1. Front Matter
      Pages 9-10
    2. R. A. Chalmers, A. M. Lawson
      Pages 11-26
    3. R. A. Chalmers, A. M. Lawson
      Pages 27-45
    4. R. A. Chalmers, A. M. Lawson
      Pages 46-82
    5. R. A. Chalmers, A. M. Lawson
      Pages 83-127
    6. R. A. Chalmers, A. M. Lawson
      Pages 128-135
    7. Back Matter
      Pages 136-160
  4. Organic acids in physiological fluids from normal subjects

    1. Front Matter
      Pages 161-162
    2. R. A. Chalmers, A. M. Lawson
      Pages 196-203
    3. Back Matter
      Pages 204-208
  5. Organic acids in human metabolic diseases (the organic acidurias)

    1. Front Matter
      Pages 209-209
    2. R. A. Chalmers, A. M. Lawson
      Pages 211-238
    3. R. A. Chalmers, A. M. Lawson
      Pages 239-295
    4. R. A. Chalmers, A. M. Lawson
      Pages 296-331
    5. R. A. Chalmers, A. M. Lawson
      Pages 332-337
    6. R. A. Chalmers, A. M. Lawson
      Pages 338-349
    7. R. A. Chalmers, A. M. Lawson
      Pages 350-382
    8. R. A. Chalmers, A. M. Lawson
      Pages 383-404
    9. R. A. Chalmers, A. M. Lawson
      Pages 405-445
  6. Erratum

    1. R. A. Chalmers, A. M. Lawson
      Pages 524-524
  7. Back Matter
    Pages 447-523

About this book

Introduction

The writing of this book was prompted by the need for a comprehensive of current data on organic acids suitable for both newcomers and collection established researchers in this field. The only previous text of the kind was the excellent review by Nordmann and Nordmann (1961), and at that time the main method of analysis was paper chromatography with liquid chromatography being used in a limited way. Only three diseases in which organic acids accumulate were known (primary hyperoxaluria, phenylketonuria and alcaptonuria). Since then, with the development of gas chromatography and mass spectrometry, and the further development ofliquid chromatography, knowledge concerning the nature of the organic acids in physiological fluids has been greatly extended. At the same time, the number of organic acidurias has increased dramatically, there being now some 40-50 known diseases of this type. During the past 15 years or so, there have been several reviews, dealing with either specific diseases or groups of diseases (Gompertz, 1972, 1974; Tanaka, 1975), or presenting the proceedings of symposia (Stern and Toothill, 1972) or workshops (Marner et al. , 1974). This present text deals comprehensively and in detail with the organic acids in human physiological fluids in health and in disease states, and is particularly concerned with the methods necessary for their separation, determination and indentification.

Keywords

Alanin amino acid biochemistry chromatography metabolism organic acid physiological fluid

Authors and affiliations

  • R. A. Chalmers
    • 1
  • A. M. Lawson
    • 1
  1. 1.M.R.C. Clinical Research CentreHarrowUK

Bibliographic information

  • DOI https://doi.org/10.1007/978-94-009-5778-7
  • Copyright Information R. A. Chalmers and A. M. Lawson 1982
  • Publisher Name Springer, Dordrecht
  • eBook Packages Springer Book Archive
  • Print ISBN 978-94-009-5780-0
  • Online ISBN 978-94-009-5778-7
  • Buy this book on publisher's site