Enzyme Chemistry

1. Front Matter

   Pages i-xii

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2. Infant enzyme chemistry

   • Colin J. Suckling

   Pages 1-7

3. The mechanistic basis of enzyme catalysis

   • Ronald Kluger

   Pages 8-49

4. Chemical models of selected coenzyme catalyses

   • Seiji Shinkai

   Pages 50-94

5. Selectivity in synthesis — chemicals or enzymes?

   • Colin J. Suckling

   Pages 95-170

6. Enzymes as targets for drug design

   • Philip D. Edwards, Barrie Hesp, D. Amy Trainor, Alvin K. Willard

   Pages 171-226

7. The impact of metal ion chemistry on our understanding of enzymes

   • Donald H. Brown, W. Ewan Smith

   Pages 227-264

8. The enzymology of the biosynthesis of natural products

   • David E. Cane

   Pages 265-305

9. Enzymes in the food industry

   • David R. Berry, Alistair Paterson

   Pages 306-351

10. Enzymology and protein chemistry in the wider area of biology

    • Keith E. Suckling

    Pages 352-373

11. Back Matter

    Pages 375-383

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As the first edition of this book was going through the publication process, a revolution was taking place in the technologies available for the study of enzymes. The techniques of molecular biology, especially in genetic engineering of organisms and in site specific mutagenesis of genes, were established and were being brought into use to solve many problems in in enzymology. Added to these fundamental and applied science, not least advances the possibility of generating catalysts from antibodies has become a topic of major interest. These major innovations have changed the emphasis of much bioorganic research; whereas in the past, the protein was often the 'sleeping partner' ina study, its detailed function is now the major focus of scientific interest. Similarly in industry, the potential of genetically manipulated organisms to satisfy the needs for the production of chemicals and foodstuffs has been widely recognised. The second edition of 'Enzyme Chemistry, Impact and Applications' takes on board these new develop­ ments whilst maintaining the overall aims and views of the first edition. Many of the chapters have been completely rewritten to take account of advances in the last five years especially with regard to the impact of biologically based technologies. Although the book continues to approach its subject matter from the point of view of the chemist, the increased interdisciplinary content of much modern science will be obvious from the discussion.

• Coenzym
• DNA
• Oligosaccharid
• enzymes
• natural product
• proteins

• Department of Pure and Applied Chemistry, University of Strathclyde, Glasgow, UK

  Colin J. Suckling

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