Photochemical Probes in Biochemistry

  • Peter E. Nielsen

Part of the NATO ASI Series book series (ASIC, volume 272)

Table of contents

  1. Front Matter
    Pages i-ix
  2. Ole Buchardt, Ulla Henriksen, Troels Koch, Peter E. Nielsen
    Pages 1-9
  3. Cesare Montecucco, Giampietro Schiavo, Emanuele Papini, Maurizio Tomasi, Roberto Bisson
    Pages 43-58
  4. A. N. Eberle, F. Solca, W. Siegrist, T. Scimonelli, J. Girard, P. N. E. de Graan
    Pages 67-84
  5. F. Kotzyba-Hibert, A. Jaganathen, J. Langenbuch-Cachat, M. Goeldner, C. Hirth, M. Dennis et al.
    Pages 85-105
  6. L. Ehret-Sabatier, B. Kieffer, M. P. Goeldner, C. G. Hirth
    Pages 107-122
  7. Barry S. Cooperman, Melissa A. Buck, Carmen L. Fernandez, Carl J. Weitzmann, Barbara F. D. Ghrist
    Pages 123-139
  8. Suzanne Cheng, Howard B. Gamper, John E. Hearst
    Pages 169-177
  9. Ole Buchardt, Gunnar Karup, Michael Egholm, Troels Koch, Ulla Henriksen, Morten Meldal et al.
    Pages 209-218
  10. Peter E. Nielsen, Claus Jeppesen
    Pages 231-240

About this book

Introduction

The concept of using photochemical probes in the study of biological systems was developed by Westheimer who published the first photoaffinity labeling experiments more than twenty years ago (J.Bio1. Chem. 237, (1962) 3006). Since then the concept has been used successfully in various areas of biochemistry and recently several new interesting and exciting aspects of the concept have been developed. It is the general opinion by scientists in the "field" that the full potential of photochemical probes in biochemical studies has far from been exploited yet. This is mostly due to the interdisciplinary character of the concept involving photochemistry, synthetic chemistry as well as biochemistry/molecular biology. The perspective of the NATO advanced workshop on "Photochemical Probes in Biochemistry", held in Holte (Copenhagen) Denmark 14-19, August, 1988, was several fold. The workshop was to give an account of the "state of the art" of using photochemical probes in biochemistry as well as to bring together specialists in photochemistry, syn­ thetic chemistry and molecular biology in order to analyze advantages as well as the inherent problems and pitfalls of the concept and provide suggestions and guidelines for fu­ ture research. Furthermore, it is the hope of the editor that the present publication which gives an account of the lectures presented at the workshop, will provide an introduction to scientists who are not familiar with photochemical probes, but to whom these could help answer central and pertinent questions.

Keywords

ATP DNA Nucleotide RNA biochemistry skeleton transcription

Editors and affiliations

  • Peter E. Nielsen
    • 1
  1. 1.Department of Biochemistry BUniversity of Copenhagen The Panum InstituteCopenhagenDenmark

Bibliographic information

  • DOI https://doi.org/10.1007/978-94-009-0925-0
  • Copyright Information Springer Science+Business Media B.V. 1989
  • Publisher Name Springer, Dordrecht
  • eBook Packages Springer Book Archive
  • Print ISBN 978-94-010-6905-2
  • Online ISBN 978-94-009-0925-0
  • Series Print ISSN 1389-2185
  • About this book
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