Interrelations between Essential Metal Ions and Human Diseases

  • Astrid Sigel
  • Helmut Sigel
  • Roland K.O. Sigel

Part of the Metal Ions in Life Sciences book series (MILS, volume 13)

Table of contents

  1. Front Matter
    Pages i-xxxvii
  2. Hana R. Pohl, John S. Wheeler, H. Edward Murray
    Pages 29-47
  3. Andrea M. P. Romani
    Pages 49-79
  4. Marisa Brini, Denis Ottolini, Tito Calì, Ernesto Carafoli
    Pages 81-137
  5. Dieter Rehder
    Pages 139-169
  6. Daiana Silva Avila, Robson Luiz Puntel, Michael Aschner
    Pages 199-227
  7. Robert C. Hider, Xiaole Kong
    Pages 229-294
  8. Kazuhiro Yamada
    Pages 295-320
  9. Barbara Zambelli, Stefano Ciurli
    Pages 321-357
  10. Ivo Scheiber, Ralf Dringen, Julian F. B. Mercer
    Pages 359-387
  11. Wolfgang Maret
    Pages 389-414
  12. Guenter Schwarz, Abdel A. Belaidi
    Pages 415-450
  13. Keith R. Martin
    Pages 451-473
  14. Suguru Kurokawa, Marla J. Berry
    Pages 499-534
  15. Back Matter
    Pages 535-573

About this book


MILS-13 provides an up-to-date review on the relationships between essential metals and human diseases, covering 13 metals and 3 metalloids: The bulk metals sodium, potassium, magnesium, and calcium, plus the trace elements manganese, iron, cobalt, copper, zinc, molybdenum, and selenium, all of which are essential for life. Also covered are chromium, vanadium, nickel, silicon, and arsenic, which have been proposed as being essential for humans in the 2nd half of the last century. However, if at all, they are needed only in ultra-trace amounts, and because of their prevalence in the environment, it has been difficult to prove whether or not they are required. In any case, all these elements are toxic in higher concentrations and therefore, transport and cellular concentrations of at least the essential ones, are tightly controlled; hence, their homeostasis and role for life, including deficiency or overload, and their links to illnesses, including cancer and neurological disorders, are thoroughly discussed. Indeed, it is an old wisdom that metals are indispensable for life. Therefore, Volume 13 provides in an authoritative and timely manner in 16 stimulating chapters, written by 29 internationally recognized experts from 7 nations, and supported by more than 2750 references, and over 20 tables and 80 illustrations, many in color, a most up-to-date view on the vibrant research area of the Interrelations between Essential Metal Ions and Human Diseases.

Astrid Sigel, Helmut Sigel, and Roland K. O. Sigel have long-standing interests in Biological Inorganic Chemistry. Their research focuses on metal ion interactions with nucleotides and nucleic acids and on related topics. They edited previously 44 volumes in the series Metal Ions in Biological Systems.


Essential Metals Human Diseases Metal Deficiency Metal Homeostasis Metal Overload

Editors and affiliations

  • Astrid Sigel
    • 1
  • Helmut Sigel
    • 2
  • Roland K.O. Sigel
    • 3
  1. 1.Dept. of Chemistry, Inorganic ChemistryUniversity of BaselBaselSwitzerland
  2. 2.Department of Chemistry, Inorganic ChemistryUniversity of BaselBaselSwitzerland
  3. 3.Institute of Inorganic ChemistryUniversity of ZürichZürichSwitzerland

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media Dordrecht 2013
  • Publisher Name Springer, Dordrecht
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-94-007-7499-5
  • Online ISBN 978-94-007-7500-8
  • Series Print ISSN 1559-0836
  • Series Online ISSN 1868-0402
  • Buy this book on publisher's site
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