Desmoid Tumors

  • Charisse Litchman

Table of contents

  1. Front Matter
    Pages 1-1
  2. The Identification and Treatment of Desmoid Tumors

    1. Front Matter
      Pages 3-3
    2. Charisse Litchman
      Pages 1-2
    3. Anastasia Constantinidou, Michelle Scurr, Ian Judson, Charisse Litchman
      Pages 5-16
    4. Wai Chin Foo, Alexander J. Lazar
      Pages 17-28
    5. Robert A. Lefkowitz, Sinchun Hwang, Jonathan Landa
      Pages 47-75
    6. Paxton V. Dickson, Raphael Pollock
      Pages 77-90
    7. Andrea Marrari, Suzanne George
      Pages 91-104
    8. Hani O. Al-Halabi, Yen-Lin Chen, John T. Mullen, Sam S. Yoon, Francis J. Hornicek, Thomas F. DeLaney
      Pages 105-125
    9. David S. Pryluck, Joseph P. Erinjeri
      Pages 127-144
  3. Special Populations with Desmoid Tumors

    1. Front Matter
      Pages 145-145
    2. Aaron R. Weiss, Anthony Montag, Stephen X. Skapek
      Pages 159-178
  4. Considerations for Current and Future Advancement in the Search for a Cure

    1. Front Matter
      Pages 179-179
    2. Benjamin Alman
      Pages 195-203
  5. Back Matter
    Pages 209-209

About this book

Introduction

Desmoid Tumors (DT), also called Aggressive Fibromatoses, are a rare fibroblastic proliferative disease, with an incidence of 2 to 4 new cases per million people per year. Despite the absence of a metastatic potential, DT cause significant morbidity and at times mortality due to its locally invasive behaviour. The anatomical locations can be abdominal, extra-abdominal (often in the extremities) and intra-abdominal. This book is the first manuscript dedicated entirely to Desmoid Tumors. Written by prominent clinicians, researchers and advocacy group experts, patients and professionals alike will find this to be a comprehensive review. Clinical presentation, imaging guidelines and treatment paradigms are highlighted. Both the sporadic and heredity forms (Familial Adenomatous Polyposis) will be discussed. A thorough discussion on the unique issues in children with DT is included. A portion of the book will address the role of the APC gene, the β-catenin protein and the role of mutations in the genesis of DT. Emerging cutting edge research techniques will be revealed. Also included is a thoughtful discussion on the controversial labelling of Desmoid Tumors as benign and the consequences of such a designation. The role of advocacy groups in supporting research and in promoting awareness of rare diseases such as DT will be outlined. This book will serve as basis to prepare clinicians, researchers and patients to embark on the quest for a cure for Desmoid Tumors.

Keywords

APC Aggressive Fibromatosis Desmoid Tumor Familial Adenomatous Polyposis β-catenin

Editors and affiliations

  • Charisse Litchman
    • 1
  1. 1., Department of NeurologyColumbia UniversityStamfordUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-94-007-1685-8
  • Copyright Information Springer Science+Business Media B.V. 2012
  • Publisher Name Springer, Dordrecht
  • eBook Packages Medicine
  • Print ISBN 978-94-007-1684-1
  • Online ISBN 978-94-007-1685-8
  • About this book
Industry Sectors
Biotechnology
Pharma