Mouse as a Model Organism

From Animals to Cells

  • Cord Brakebusch
  • Taina Pihlajaniemi

Table of contents

  1. Front Matter
    Pages i-xiv
  2. Eduardo Moltó, Cristina Vicente-García, Almudena Fernández, Lluís Montoliu
    Pages 1-10
  3. Valérie Gailus-Durner, Beatrix Naton, Thure Adler, Luciana Afonso, Juan Antonio Aguilar-Pimentel, Lore Becker et al.
    Pages 11-44
  4. Ritva Heljasvaara, Taina Pihlajaniemi
    Pages 89-104
  5. Anne Masset, Mehdi El Hour, Sarah Berndt, Nor Eddine Sounni, Agnès Noel
    Pages 105-115
  6. Donald Gullberg, Rolf K. Reed
    Pages 117-130
  7. An Hendrix, Koen Jacobs, Astrid De Boeck, Wendy Westbroek, Marc Bracke, Olivier De Wever
    Pages 131-143
  8. Back Matter
    Pages 163-165

About this book

Introduction

Cell culture based research is important for our understanding of biological processes at the cellular and molecular level. Using this approach, the previous decades have produced a wealth of mechanistic information in all areas of biomedical research. Such in vitro research, however, lacks the complexity of in vivo investigations, where many different cell types interact with each other in a normal, three-dimensional environment, with normal levels of cytokines and growth factors. Furthermore, complex human diseases, such as cancer, diabetes or chronic inflammation, can only be modeled in vivo. Due to its small size, its short reproduction time, and the possibility to introduce specific gene mutations, the mouse has become the favourite mammalian model organism to study in vivo function of genes during development and in disease. This book combines review articles on selected subjects presented at the symposium “Mouse as a Model Organism – From Animals to Cells”, held in Rovaniemi, Finland, 2009. Among other topics, high-throughput phenotyping of mouse mutants, mouse phenotypes dependent on nature and nuture, and a spectrum of in vivo, ex vivo and in vitro methods to study cancer in mice are described. This book will give an excellent introduction to scientists interested in the use of mice as a model to understand complex biological questions in the post-genomic era. It will highlight the possibilities, but also discuss the current problems and shortcomings, to give a realistic view of the current state-of-art in this fascinating field of biomedical research.

Keywords

Animal Models Biological Techniques Genetic and Genomics Mouse Transgenics

Editors and affiliations

  • Cord Brakebusch
    • 1
  • Taina Pihlajaniemi
    • 2
  1. 1., Institute of Biomedicine, BRICUniversity of CopenhagenCopenhagenDenmark
  2. 2.Oulu Center for Cell-Matrix ResearchOuluFinland

Bibliographic information

  • DOI https://doi.org/10.1007/978-94-007-0750-4
  • Copyright Information Springer Science+Business Media B.V. 2011
  • Publisher Name Springer, Dordrecht
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-94-007-0749-8
  • Online ISBN 978-94-007-0750-4
  • About this book
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