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A3 Adenosine Receptors from Cell Biology to Pharmacology and Therapeutics

  • Pier Andrea Borea

Table of contents

  1. Front Matter
    Pages i-xv
  2. Introduction

  3. Physico-chemical Properties and Molecular Biology

    1. Front Matter
      Pages 28-28
    2. Pier Andrea Borea, Stefania Gessi, Stefania Merighi, Katia Varani
      Pages 29-48
  4. Signal Transduction

    1. Front Matter
      Pages 60-60
    2. Stefania Merighi, Carolina Simioni, Rob Lane, Adriaan P. Ijzerman
      Pages 61-73
    3. Maria Letizia Trincavelli, Osele Ciampi, Claudia Martini
      Pages 75-90
  5. Medicinal Chemistry

    1. Front Matter
      Pages 92-92
    2. Kenneth A. Jacobson, Zhan-Guo Gao, Dilip K. Tosh, Gangadhar J. Sanjayan, Sonia de Castro
      Pages 93-120
    3. Pier Giovanni Baraldi, Romeo Romagnoli, Giulia Saponaro, Stefania Baraldi, Mojgan Aghazadeh Tabrizi, Delia Preti
      Pages 121-147
    4. Stefano Moro, Erika Morizzo, Kenneth A. Jacobson
      Pages 149-161
  6. Effects on Tissues and Organs and Therapeutic Applications

    1. Front Matter
      Pages 164-164
    2. Felicita Pedata, Anna Maria Pugliese, Ana M. Sebastião, Joaquim A. Ribeiro
      Pages 165-188
    3. John P. Headrick, Jason N. Peart, Tina C. Wan, Wai-Meng Kwok, John A. Auchampach
      Pages 189-208
    4. Yifat Klein, Idit Matot
      Pages 209-233
    5. Stefania Gessi, Valerio Sacchetto, Eleonora Fogli, John Fozard
      Pages 235-256
    6. Bruce T. Liang, Maria Urso, Edward Zambraski, Kenneth A. Jacobson
      Pages 257-280
    7. Stefania Gessi, Stephen MacLennan, Edward Leung, Pier Andrea Borea
      Pages 281-288
  7. Inflammatory and Auto-Immune Diseases

    1. Front Matter
      Pages 290-290
  8. Cancer

    1. Front Matter
      Pages 300-300
    2. Pnina Fishman, Sara Bar-Yehuda, Katia Varani, Stefania Gessi, Stefania Merighi, Pier Andrea Borea
      Pages 301-317
  9. Back Matter
    Pages 319-322

About this book

Introduction

This Book "A3 Adenosine Receptors from Cell Biology to Pharmacology and Therapeutics " documents the present state of knowledge of the adenosine A3 receptor. Adenosine A3 receptors are G protein-linked receptors that function in physiology and intracellular signaling and are involved in inflammatory responses and mediating cell proliferation and cell death.

The A3 receptor is increasingly being recognized for its biological roles throughout the body, and many A3 receptor ligands have proven useful in elucidating peripheral and central pathologies. This book covers a wide range of information including data from studies of theoretical, molecular and cellular pharmacology, signal transduction, integrative physiology, new drug discoveries and clinical applications. The book includes sections on:

  • A3 Adenosine Receptor signal transduction
  • Adenosine Receptor medicinal chemistry
  • Effects and therapeutic applications of Adenosine Receptors on tissues and organs
  • Adenosine Receptors and inflammatory and auto-immune diseases
  • Adenosine Receptors and cancer

The chapters in this book cover both fundamental science and relevant applications and provide an authoritative account of the current status of the field. "A3 Adenosine Receptors from Cell Biology to Pharmacology and Therapeutics" is an up to date and scientifically excellent source of information, attractive to basic and clinical scientists alike.

Keywords

Asthma Regulation biology cardiovascular cell biology chemistry hypertension medicinal chemistry physiology tissue

Editors and affiliations

  • Pier Andrea Borea
    • 1
  1. 1.Ist. FarmacologiaUniversita FerraraFerraraItaly

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