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Supramolecular Chemistry

From Biological Inspiration to Biomedical Applications

  • Peter J. Cragg

Table of contents

  1. Front Matter
    Pages i-xv
  2. Peter J. Cragg
    Pages 91-111
  3. Peter J. Cragg
    Pages 113-151
  4. Peter J. Cragg
    Pages 153-183
  5. Peter J. Cragg
    Pages 185-206
  6. Peter J. Cragg
    Pages 207-229
  7. Peter J. Cragg
    Pages 231-256
  8. Back Matter
    Pages 257-260

About this book

Introduction

Supramolecular chemistry is often described as the study of chemistry beyond the simple molecular level yet it is often forgotten how many of the pioneering su-pramolecular chemists looked to molecular biology for their ideas. The search for an aldolase enzyme mimic, the discovery of crown ethers that transported potas-sium as efficiently as valinomycin, and the synthesis of an antitubercular com-pound that resembled a transmembrane protein, all point to a biological inspira-tion. Since the field emerged in the last quarter of the 20th Century, advances in the synthesis of multifunctional molecules, coupled to a greater understanding of biological processes at the molecular level, have led supramolecular chemists to design compounds that not only mimic those in Nature but also have diagnostic and therapeutic applications.

The book opens with an overview of supramolecular chemistry. In subsequent chapters parallels are drawn with biological phenomena: the formation of proteins and other biomolecules, the evolution of cells, and the design of channel-forming molecules and enzymes. The application of supramolecular principles to sensors and magic bullet therapies is explained and the future of supramolecular therapeutics is considered. The exciting combination of supramolecular chemistry and nanotechnology is discussed together with the likelihood that nanoengineered smart materials could one day circulate in the body to treat patients before they became aware of any symptoms.

Supramolecular Chemistry: From Biological Inspiration to Biomedical Applications is aimed at postgraduates working at the chemistry/life science interface and final year undergraduate advanced options in supramolecular chemistry. It is hoped that it will also be of value to academics and professionals interested in the relevance of supramolecular chemistry to biology and vice versa.

Keywords

Biomedical Applications Biomimetics Drug Delivery Photodynamic Therapy Supramolecular Chemistry Therapeutic Chemistry chemistry

Authors and affiliations

  • Peter J. Cragg
    • 1
  1. 1.School of Pharmacy &, Biomolecular SciencesUniversity of BrightonBrightonUnited Kingdom

Bibliographic information

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