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From Molecules to Medicines

Structure of Biological Macromolecules and Its Relevance in Combating New Diseases and Bioterrorism

  • Joel L. Sussman
  • Paola Spadon
Conference proceedings

Part of the NATO Science for Peace and Security Series A: Chemistry and Biology book series (NAPSA)

Table of contents

  1. Front Matter
    Pages i-xv
    PDF
  2. Surface Proteins of Gram-Positive Pathogens: Using Crystallography to Uncover Novel Features in Drug and Vaccine Candidates
    Edward N. Baker, Thomas Proft, Haejoo Kang
    Pages 1-9
  3. The Rapid Crystallization Strategy for Structure-Based Inhibitor Design
    Terese Bergfors
    Pages 11-19
  4. Fragment-Based Drug Discovery in Academia: Experiences From a Tuberculosis Programme
    Timo J. Heikkila, Sachin Surade, Hernani L. Silvestre, Marcio V. B. Dias, Alessio Ciulli, Karen Bromfield et al.
    Pages 21-36
  5. Structural Biology Contributions to the Discovery of Drugs to Treat Chronic Myelogenous Leukemia
    Sandra W. Cowan-Jacob, Gabriele Fendrich, Andreas Floersheimer, Pascal Furet, Janis Liebetanz, Gabriele Rummel et al.
    Pages 37-61
  6. Integrating Crystallography into Early Metabolism Studies
    Gabriele Cruciani, Yasmin Aristei, Laura Goracci, Emanuele Carosati
    Pages 63-77
  7. The Foundations of Protein–Ligand Interaction
    Gerhard Klebe
    Pages 79-101
  8. Structure-Based Design of Trna-Guanine Transglycosylase Inhibitors
    Gerhard Klebe
    Pages 103-120
  9. Progress on New Hepatitis C Virus Targets: NS2 and NS5A
    Joseph Marcotrigiano
    Pages 121-138
  10. Protein Structure Modeling
    Narayanan Eswar, Andrej Sali
    Pages 139-151
  11. Structural Biology and Molecular Modeling in the Design of Novel DPP-4 Inhibitors
    Giovanna Scapin
    Pages 153-168
  12. Tools to Make 3D Structural Data More Comprehensible: Emovie & Proteopedia
    Eran Hodis, Jaime Prilusky, Joel L. Sussman
    Pages 169-182
  13. Structural Studies on Acetylcholinesterase and Paraoxonase Directed Towards Development of Therapeutic Biomolecules for the Treatment of Degenerative Diseases and Protection Against Chemical Threat Agents
    Joel L. Sussman, Israel Silman
    Pages 183-199
  14. Protein Function Prediction from Structure in Structural Genomics and its Contribution to the Study of Health and Disease
    James D. Watson, Janet M. Thornton
    Pages 201-215
  15. Crystal Structures of the β2-Adrenergic Receptor
    William I. Weis, Daniel M. Rosenbaum, Søren G. F. Rasmussen, Hee-Jung Choi, Foon Sun Thian, Tong Sun Kobilka et al.
    Pages 217-230
  16. Can Structures Lead to Better Drugs? Lessons from Ribosome Research
    Ada Yonath
    Pages 231-251

About these proceedings

Keywords

3D Biology Chemistry NATO Peace Science Security Sub-Series A computational chemistry crystallography genome lead metabolism molecular modeling structural biology

Editors and affiliations

  • Joel L. Sussman
    • 1
  • Paola Spadon
    • 2
  1. 1.Department of Structural BiologyWeizmann Institute of ScienceRehovotIsrael
  2. 2.Department of Chemical SciencesUniversity of PadovaItaly

Bibliographic information

  • DOI https://doi.org/10.1007/978-90-481-2339-1
  • Copyright Information Springer Netherlands 2009
  • Publisher Name Springer, Dordrecht
  • eBook Packages Physics and Astronomy
  • Print ISBN 978-90-481-2338-4
  • Online ISBN 978-90-481-2339-1
  • Series Print ISSN 1874-6489
  • Buy this book on publisher's site
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