Overview
- Editors:
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Francesco Saverio De Ponte
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, Dental Department, University of Messina, Messina, Italy
- First multidisciplinary text on the subject, by worldwide experts
- Update of the latest advances, technical details, and expert advice regarding this subject
- Presents multiple designs, explanatory figures on physiopathogenesis, and clinical imaging
- Clinical case discussions and practical advice for incorporation into common practice
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Table of contents (15 chapters)
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Front Matter
Pages i-xiii
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- Angelina De Sarro, Letteria Minutoli
Pages 13-22
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- Giuseppe Altavilla, Grazia Marabello, Chiara Tomasello, Vincenzo Pitini
Pages 23-34
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- Caterina Musolino, Alessandro Allegra
Pages 35-48
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- Angelina De Sarro, Letteria Minutoli
Pages 49-57
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- Santino Ferrara, Laura Vuolo, Annamaria Colao, Luigi Califano
Pages 73-84
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- Silvio Mazziotti, Achille Mileto, Michele Gaeta, Giorgio Ascenti, Ignazio Salamone, Carmela Visalli et al.
Pages 85-95
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- Stefania Leuci, Marco Friscia, Michele Davide Mignogna
Pages 97-103
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- Claudio Marchetti, Gian Andrea Pelliccioni, Filippo Moretti, Francesco Saverio De Ponte, Giuseppe Lombardo, Carla Nava
Pages 141-156
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- Luciano Catalfamo, Carla Nava, Giuseppe Lombardo, Francesco Saverio De Ponte
Pages 157-166
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Back Matter
Pages 179-181
About this book
During the early 19th century, it was discovered that adding yellow (now called white) phosphorous to matchstick heads made it easier to ignite matches. The phosphorous vapors were breathed in by workers and combined with other chemicals in the body to produce a potent nitrogen-containing bisphosphonate. Today's oral nitrogen-containing bisphosphonates and intravenous nitrogen-containing bisphosphonates circulate around the body the same way as the phosphorous vapors, and are absorbed into bone and ingested by osteoclasts. When this unique binding process of bisphosphonates to bone occurs, osteoclasts are poisoned, and this reduces or eliminates bone turnover. Alveolar bone in the mandible and maxilla turns over more rapidly than in long bones, so the jaws are a better target for bisphosphonate toxicity. It wasn't until 2003 that today's intravenous and oral nitrogen-containing bisphosphonate medications were implicated as major risk factors in the development of exposed necrotic boneof the jaws. Most of the researchers who reported cases of bisphosphonate-induced osteonecrosis of the jaw found that these patients were treated with zoledronate, pamidronate, or a combination of these drugs, which are commonly used for treating breast cancer or myeloma. In about 5% of cases, subjects with BIONJ were being treated for osteoporosis. Precipitating events that contribute to BIONJ are tooth extractions (about 50% of cases), mandibular exostoses, periodontal disease, and local trauma from ill-fitting dentures. It is not known if the placement of dental implants is a precipitating factor. The book aims to meet the need of medical practitioners working in all fields that use bisphosphonates, and to present the conservative and surgical treatment methods currently in use. There will also be detailed information on the literature relating to dental implants in patients treated with bisphosphonates.
