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Quorum Sensing vs Quorum Quenching: A Battle with No End in Sight

  • Book
  • © 2015

Overview

Editors:
  1. Vipin Chandra Kalia

    1. CSIR-Institute of Genomics and Integrative Biology, Microbial Biotechnology and Genomics, Delhi, India

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  • Defines quorum sensing (QS) systems as the global regulators of bacterial genes expression
  • Discusses the potential of QS regulation as a new drug target for the treatment of bacterial infections
  • Addresses to the increasing demand of antibiotic-resistant bacteria for novel strategies to control infectious diseases
  • Includes supplementary material: sn.pub/extras

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Table of contents (31 chapters)

  1. Detectors for Quorum Sensing Signals

    1. Caenorhabditis elegans as an In Vivo Non-Mammalian Model System to Study Quorum Sensing in Pathogens

      • Sajal Sarabhai, Neena Capalash, Prince Sharma
      Pages 185-195

    2. Strategies for Silencing Bacterial Communication

      • Kristina Ivanova, Margarida M. Fernandes, Tzanko Tzanov
      Pages 197-216

  2. Natural Quorum Sensing Inhibitors

    1. Front Matter

      Pages 217-217
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    2. Silencing Bacterial Communication Through Enzymatic Quorum-Sensing Inhibition

      • Manuel Romero, Celia Mayer, Andrea Muras, Ana Otero
      Pages 219-236

    3. Fungal Quorum Sensing Inhibitors

      • Rohit Sharma, Kamlesh Jangid
      Pages 237-257

    4. Marine Organisms as Source of Quorum Sensing Inhibitors

      • Fohad Mabood Husain, Iqbal Ahmad
      Pages 259-268

    5. Plant Quorum Sensing Inhibitors: Food, Medicinal Plants, and Others

      • Pragasam Viswanathan, Prasanth Rathinam, Suneeva S. C.
      Pages 269-281

  3. Synthetic Quorum Sensing Inhibitors

    1. Front Matter

      Pages 283-283
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    2. Synthetic Quorum Sensing Inhibitors: Signal Analogues

      • Dimpy Kalia
      Pages 285-302

    3. Synthetic Quorum Sensing Inhibitors (QSIs) Blocking Receptor Signaling or Signal Molecule Biosynthesis in Pseudomonas aeruginosa

      • Christine K. Maurer, Cenbin Lu, Martin Empting, Rolf W. Hartmann
      Pages 303-317

    4. Development of Quorum-Sensing Inhibitors Targeting the fsr System of Enterococcus faecalis

      • Ravindra Pal Singh, Jiro Nakayama
      Pages 319-324

  4. Alternative Strategies as Quorum Sensing Inhibitors

    1. Front Matter

      Pages 325-325
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    2. An Alternative Strategy as Quorum-Sensing Inhibitor: Pheromone-Guided Antimicrobial Peptides

      • Yung-Hua Li, Xiao-Lin Tian
      Pages 327-334

    3. Alternative Strategies to Target Quorum Sensing (QS): Combination of QS Inhibitors with Antibiotics and Nanotechnological Approaches

      • Divakara S. S. M. Uppu, Chandradhish Ghosh, Jayanta Haldar
      Pages 335-342

    4. Heterologous Expression of Quorum Sensing Inhibitory Genes in Diverse Organisms

      • Prasun Kumar, Shikha Koul, Sanjay K. S. Patel, Jung-Kul Lee, Vipin C. Kalia
      Pages 343-356

  5. Biotechnological Applications of Quorum Sensing Inhibitors

    1. Front Matter

      Pages 357-357
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    2. Potential Applications of Quorum Sensing Inhibitors in Diverse Fields

      • Vipin C. Kalia, Prasun Kumar
      Pages 359-370

    3. Biotechnological Applications of Quorum-Sensing Inhibitors in Aquacultures

      • Faseela Hamza, Ameeta Ravi Kumar, Smita Zinjarde
      Pages 371-383

    4. The Battle: Quorum-Sensing Inhibitors Versus Evolution of Bacterial Resistance

      • Vipin C. Kalia, Prasun Kumar
      Pages 385-391
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Keywords

About this book

Microbial relationships with all life forms can be as free living, symbiotic or pathogenic. Human beings harbor 10 times more microbial cells than their own. Bacteria are found on the skin surface, in the gut and other body parts. Bacteria causing diseases are the most worrisome. Most of the infectious diseases are caused by bacterial pathogens with an ability to form biofilm. Bacteria within the biofilm are up to 1000 times more resistant to antibiotics. This has taken a more serious turn with the evolution of multiple drug resistant bacteria. Health Departments are making efforts to reduce high mortality and morbidity in man caused by them. Bacterial Quorum sensing (QS), a cell density dependent phenomenon is responsible for a wide range of expressions such as pathogenesis, biofilm formation, competence, sporulation, nitrogen fixation, etc. Majority of these organisms that are important for medical, agriculture, aquaculture, water treatment and remediation, archaeological departments are: Aeromonas, Acinetobacter, Bacillus, Clostridia, Enterococcus, Pseudomonas, Vibrio and Yersinia spp. Biosensors and models have been developed to detect QS systems. Strategies for inhibiting QS system through natural and synthetic compounds have been presented here. The biotechnological applications of QS inhibitors (QSIs) in diverse areas have also been dealt with. Although QSIs do not affect growth and are less likely to impose selective pressure on bacteria, however, a few reports have raised doubts on the fate of QSIs. This book addresses a few questions. Will bacteria develop mechanisms to evade QSIs? Are we watching yet another defeat at the hands of bacteria? Or will we be acting intelligently and survive the onslaughts of this Never Ending battle?

Editors and Affiliations

  • CSIR-Institute of Genomics and Integrative Biology, Microbial Biotechnology and Genomics, Delhi, India

    Vipin Chandra Kalia

About the editor

Dr. Vipin Chandra Kalia is presently working as Chief Scientist, Microbial Biotechnology and Genomics, CSIR- Institute of Genomics and Integrative Biology. He is a Professor, AcSIR who obtained his M.Sc. and Ph.D. Genetics, from Indian Agricultural Research Institute, New Delhi. He has been elected as: (i) Fellow of Association of Microbiologists of India (FAMI), and (ii) Fellow of National Academy of Sciences (FNASc). His main areas of Research are Microbial Biodiversity, Bioenergy, Biopolymers, Genomics and Microbial Evolution; Quorum sensing, Quorum quenching, Drug Discovery and Antimicrobials. He has published 65 papers in Scientific journals such as (i) Nature Biotechnology, (ii) Biotechnology Advances, (iii) Trends in Biotechnology, (iv) Critical Reviews in Microbiology, (v) Bio resource Technology, (vi) PLoS ONE, (vii) BMC Genomics. His works have been cited 1600 times with an h index: 22; i10 index: 35. He is presently the Editor in Chief of Indian Journal of Microbiology and Editor of (i) J Microbiol & Biotechnol(Korea), (ii). Appl. Biochem. & Biotechnology (USA), (iii) International Scholarly Res. Network Renewable Energy, (iv). Dataset Papers in Microbiol. Life member of Scientific Societies: (i) Society of Biological Chemists of India (ii) Society for Plant Biochem. & Biotechnol. (India); (iii) Association of Microbiologist of India; (iv) Indian Science Congress Association; (v) BioEnergy Society of India, (vi) Biotech Res. Soc. of India. (BRSI); Member: American Society of Microbiology. He can be contacted at: vckalia@igib.res.in; vc_kalia@yahoo.co.in

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