Skip to main content
SpringerLink
Log in

Protection Against Ischemia/Reperfusion Damage of the Heart

  • Book
  • © 1998

Overview

Editors:
  1. Yasushi Abiko

    1. Department of Pharmacology, Asahikawa Medical College, Asahikawa, Japan

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  2. Morris Karmazyn

    1. Department of Pharmacology and Toxicology, The University of Western Ontario, London, Canada

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • How to protect ischemia/reperfusion damage" is one of the most important problems in medicine, but this problem remains still unsolved despite many studies

  • Through this book readers can get new information on pathophysiology of ischemia/reperfusion damage of the heart and obtain novel ideas how to develop more effective remedies for protection of the ischema/reperfusion damages

This is a preview of subscription content, log in via an institution to check access.

Access this book

Log in via an institution
eBook USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 54.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access

Licence this eBook for your library

Institutional subscriptions

Table of contents (15 chapters)

  1. Front Matter

    Pages II-IX
    Download chapter PDF

  2. Modulators of Ischemia/Reperfusion Damage H+, Na+, and Ca2+

    1. Front Matter

      Pages 1-1
      Download chapter PDF

  3. Modulators of Ischemia/Reperfusion Damage H+, Na+, and Ca2+

    1. Regulatory Mechanism of NHE1 Isoform of Na+/H+ Exchanger in Cardiac and Other Tissues

      • Munekazu Shigekawa, Toshitaro Ikeda, Takahiro Iwamoto, Shigeo Wakabayashi
      Pages 3-21

    2. Role of the Vacuolar Proton Pump in Preconditioning

      • Roberta A. Gottlieb, Robert L. Engler
      Pages 23-37

    3. Role of the Na+/Ca2+ Exchanger in Intracellular Ca2+ Overload During Ischemia and Reperfusion

      • Shingo Seki, Seibu Mochizuki
      Pages 39-48

    4. The Role of Sodium—Hydrogen Exchange in the Ischemic and Reperfused Myocardium

      • Morris Karmazyn
      Pages 49-62

  4. Modulators of Ischemia/Reperfusion Damage: Lipid Metabolites

    1. Front Matter

      Pages 63-63
      Download chapter PDF

    2. Effects of Lysophosphoglycerides on KATP Channels in Cardiac Ventricular Cells: Blockage or Rundown?

      • Toshiaki Sato, Hideaki Ozaki, Makoto Arita
      Pages 65-73

    3. Lysophosphatidylcholine: A Possible Modulator of Ischemic Injury in the Heart

      • Hiroko Hashizume, Min Chen, Hong Ma, Nina Hoque, Akiyoshi Hara, Kazuto Yazawa et al.
      Pages 75-87

    4. Potential Role of Phospholipase A2 in the Normoxic, Ischemic, and Reperfused Heart

      • Ger J. Van der Vusse, Leon J. de Windt, Sylvia W. S. Jans, Robert S. Reneman, Marc van Bilsen
      Pages 89-114

    5. Effects of Lysophosphatidylcholine on Ion Transporters in the Heart

      • Haruaki Nakaya, Seiichi Yamaguchi, Ikumi Sakashita, Nobuyuki Nakajima
      Pages 115-127

  5. Molecular Mechanisms of Myocardial and Vascular Remodeling in the Ischemic Heart

    1. Front Matter

      Pages 129-129
      Download chapter PDF

    2. Molecular Mechanism of Cardiovascular Remodeling

      • Hideaki Kawaguchi, Akira Kitabatake
      Pages 131-145

    3. Osteopontin as a Coordinator of Stress-Induced Host Responses: Molecular Analysis of Its Interaction with Various Ligands

      • Toshimitsu Uede, Yohko Katagiri, Hiroshi Hotta, Kumiko Tanaka, Junko Iizuka
      Pages 147-156

    4. Coronary Reperfusion and Cytokines

      • Akira Matsumori, Koh Ono, Shigetake Sasayama
      Pages 157-177

    5. Brief Ischemia/Reperfusion Activates Transcellular Signaling Cascades and Leads to Proto-Oncogene Expression and Growth Factor Production

      • Patrik Htun, Miro Barancik, Wolfgang Schaper
      Pages 179-192

  6. New Therapeutic Strategy to Attenuate Ischemia/Reperfusion Damage

    1. Front Matter

      Pages 193-193
      Download chapter PDF

    2. Ischemia/Reperfusion Injury and Ion Channel Blockade

      • Satoshi Takeo, Kouichi Tanonaka, Jian-Xun Liu, Toru Kamiyama, Itaru Ohoi, Hiroshi Kajiwara et al.
      Pages 195-214

    3. Energy Ameliorants: A New Category of Antianginal Drugs

      • Kazuo Ichihara, Kumi Satoh, Tohru Nakai
      Pages 215-227

    4. Strategy Toward Warm Heart Cardioplegia: Our Experimental and Clinical Experience

      • Fumio Yamamoto, Junjiro Kobayashi, Hiroaki Sasaki, Yoshiaki Suematsu, Yutaka Hino, Jun Okawara et al.
      Pages 229-241
Back to top

Keywords

About this book

How to protect against ischemia/reperfusion damage is one of the most urgent problems in medicine. It is known that ischemic damage can be attenuated by improving the oxygen balance of the ischemic heart, but the damage-producing mechanism is not yet fully understood. This book provides the latest information on the pathophysiology of ischemia/reperfusion damage and presents new ideas for more effective methods for protection. In the first two sections, the roles of such factors as various ions and phospholipids that modulate ischemia/reperfusion damage are explored, providing a clear and updated explanation of the mechanisms involved. In the third section, the myocardial and vascular remodeling procedure in hearts that have undergone ischemia/reperfusion is explained in terms of signal transduction, enabling a new understanding of the remodeling process. In the final section, a new approach to protection against ischemia/reperfusion damage is presented.

Editors and Affiliations

  • Department of Pharmacology, Asahikawa Medical College, Asahikawa, Japan

    Yasushi Abiko

  • Department of Pharmacology and Toxicology, The University of Western Ontario, London, Canada

    Morris Karmazyn

Bibliographic Information

Publish with us

Policies and ethics

Back to top

Search

Navigation