Slow Synaptic Responses and Modulation

1. Front Matter

   Pages II-XVI

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2. The Dawn and Foundation of Slow Synaptic Potentials and Modulation

   1. The Dawn and Foundation of Slow Synaptic Potentials and Modulation

      • K. Koketsu

      Pages 1-14

3. M-Currents and Modulation

   1. M-Current: From Discovery to Single Channel Currents

      • D. A. Brown

      Pages 15-26

   2. Properties of Muscarine-Sensitive Potassium Currents in Vertebrate Nerve Cells

      • T. Tokimasa, T. Nishimura

      Pages 27-34

   3. Slow Synaptic Responses in Neuronal Tumor Cells: Dual Regulation of ADP-Ribosyl Cyclase and Inhibition of M-Current by Muscarinic Receptor Stimulation

      • H. Higashida, S. Yokoyama, M. Hashii, M. Taketo

      Pages 35-41

   4. Acetylcholine-Like Effect of Sulfhydryl-Modifying Reagents on M-Current in Rodent NG108-15 Cells

      • A. B. Egorova, N. Hoshi, H. Higashida

      Pages 42-45

   5. Inhibition of M-Type K+ currents by Cognition Enhancers in NG108-15 Cells and Rat Cerebral Neurons in Culture

      • M. Noda, H. Higashida, N. Akaike

      Pages 46-48

   6. Muscarinic Inhibition of M-current in Bullfrog Sympathetic Neurones is Independent of Intracellular Ca2+ Release

      • T. Akita, K. Kuba

      Pages 49-51

4. K+ Currents and Modulation

   1. Introductory Review: K Currents and Modulation

      • D. A. Brown

      Pages 52-58

   2. The Role of Mg2+ in the Modulation of IRK3 by M1 Acetylcholine Receptor

      • H. Chuang, L. Y. Jan, Y. N. Jan

      Pages 59-66

   3. Temporal Profile of Muscarinic Modulation of the Slow Ca2+-Dependent K+ Current (IsAHP) in Rat Hippocampal Neurons

      • L. Zhang, A. A. Velumian, P. S. Pennefather, P. L. Carlen

      Pages 67-77

   4. Modulation of K+ Channels in Hippocampal Neurons: Transmitters Acting via Cyclic AMP Enhance the Excitability of Hippocampal Neurons Through Kinase-Dependent and -Independent Modulation of AHP- and h-Channels

      • J. F. Storm, P. Pedarzani, T. Haug, T. Winther

      Pages 78-92

   5. Three Types of Cerebellar Voltage-Gated K⁺ Currents Expressed in Xenopus Oocytes

      • N. Hoshi, H. Takahashi, S. Yokoyama, H. Higashida

      Pages 93-96

   6. Facilitatory Effect of Calmodulin-Dependent Protein Kinase on the K⁺-Current Responses to Dopamine, Acetylcholine, and Phe-Met-Arg-Phe-NH₂ in the Ganglion Cells of Aplysia

      • S. Kawasaki, S. Kimura, R. Fujita, K. Takashima, K. Sasaki, M. Sato

      Pages 97-100

5. Ca2+ Currents and Modulation

   1. Introductory Review: Calcium Channels and Modulation

      • L. Gandía, A. Albillos, C. Montiel, A. G. García

      Pages 101-120

   2. Neuronal T-Type Calcium Channels: Pharmacology and Investigation of Subunit Composition

      • A. Meir, C. N. Wyatt, G. J. Stephens, A. C. Dolphin

      Pages 121-129

   3. Exocytosis Calcium Channels: Autocrine/Paracrine Modulation

      • A. G. García, J. M. Hernández-Guijo, I. Mayorgas, L. Gandía

      Pages 130-146

   4. Synaptic Modulation Mediated by G-Protein-Coupled Presynaptic Receptors

      • T. Takahashi

      Pages 147-153

   5. Presynaptic Glutamate Receptors in the Hippocampus

      • H. Kamiya

      Pages 154-157

   6. The α1-Subunit of the L-Type Ca2+ Channel Is Converted to a Long Open and Noninactivating State by Large Depolarization

      • S. Nakayama, M. Kuzuya, M. Miyoshi, K. Kuba, Y. Okamura

      Pages 158-160

Information flow as nerve impulses in neuronal circuits is regulated at synapses. The synapse is therefore a key element for information processing in the brain. Much attention has been given to fast synaptic transmission, which predominantly regulates impulse-to-impulse transmission. Slow synaptic transmission and modu­ lation, however, sometimes have been neglected in considering and attempting to understand brain function. Slow synaptic potentials and modulation occur with a considerable delay in response to the accumulation of synaptic and modulatory inputs. In these contexts, they are plastic in nature and play important roles in information processing in the brain. A symposium titled "Slow Synaptic Responses and Modulation" was held as the satellite symposium to the 75th Annual Meeting of the Physiological Society of Japan on March 30-31, 1998, in Kanazawa. The theme was selected not only for the reason mentioned above, but also because of the considerable involvement of many Japanese scholars in establishing the basic issues. Following the dawn of synaptic physiological research, as Sir John Eccles, Sir Bernard Katz, and Professor Stephen Kuffler carried out pioneer work, Professor Kyozou Koketsu and Professor Benjamin Libet, the students of Sir John Eccles, and their colleagues established the concept of slow synaptic responses and modulation by studying vertebrate sympathetic ganglia. Since then, the concept has been ex­ panded with detailed investigations of both peripheral and central synapses at the levels of single ion channels, intracellular Ca"+ dynamics, intracellular transduc­ tion mechanisms, and genes.

• information
• neuroscience
• neurotransmitter
• physiology
• research

• Department of Physiology, Nagoya University School of Medicine, Showa-ku, Nagoya, Aichi, Japan

  Kenji Kuba

• Department of Biophysical Genetics, Graduate School of Medicine, Kanazawa University, Kanazawa, Ishikawa, Japan

  Haruhiro Higashida

• Department of Pharmacology, University College London, London, England, UK

  David A. Brown

• Department of Molecular Neurobiology, School of Human Science, Waseda University, Tokorozawa, Saitama, Japan

  Tohru Yoshioka

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