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Drebrin

From Structure and Function to Physiological and Pathological Roles

  • Book
  • © 2017

Overview

Editors:
  1. Tomoaki Shirao

    1. Department of Neurobiology and Behavior, Gunma University Graduate School of Medicine, Maebashi, Japan

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  2. Yuko Sekino

    1. Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Japan

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    You can also search for this editor in PubMed   Google Scholar

  • Offers the first comprehensive review of drebrin from its molecular structure and function to the physiological and pathological roles edited by the discoverer of drebrin
  • Presents a multidisciplinary review of drebrin including that of neuroscience, cancer science, immunology, and cell biology in various tissues
  • Provides the most up-to-date knowledge and intriguing hypotheses related to drebrin and drebrin-decorated F-actin by authoritative original authors of key papers
  • Includes supplementary material: sn.pub/extras
  • Includes supplementary material: sn.pub/extras

Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 1006)

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Table of contents (24 chapters)

  1. Front Matter

    Pages i-xii
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  2. History of Drebrin Discovery as an General Introduction

    1. Front Matter

      Pages 1-1
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    2. General Introduction to Drebrin

      • Tomoaki Shirao, Yuko Sekino
      Pages 3-22

  3. Basic Information About Drebrin

    1. Front Matter

      Pages 23-23
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    2. Molecular Cloning of Drebrin: Progress and Perspectives

      • Nobuhiko Kojima
      Pages 25-36

    3. Biochemistry of Drebrin and Its Binding to Actin Filaments

      • Ryoki Ishikawa
      Pages 37-47

    4. Phosphorylation of Drebrin and Its Role in Neuritogenesis

      • Phillip R. Gordon-Weeks
      Pages 49-60

    5. Remodeling of Actin Filaments by Drebrin A and Its Implications

      • Elena E. Grintsevich
      Pages 61-82

    6. Cell Shape Change by Drebrin

      • Kensuke Hayashi
      Pages 83-101

  4. Drebrin in Nervous System

    1. Front Matter

      Pages 103-103
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    2. Localization of Drebrin: Light Microscopy Study

      • Tomoaki Shirao, Noriko Koganezawa, Hiroyuki Yamazaki, Kenji Hanamura, Kazuyuki Imamura
      Pages 105-118

    3. Making of a Synapse: Recurrent Roles of Drebrin A at Excitatory Synapses Throughout Life

      • Chiye Aoki, Ang D. Sherpa
      Pages 119-139

    4. Drebrin in Neuronal Migration and Axonal Growth

      • Kenji Hanamura
      Pages 141-155

    5. Drebrin and Spine Formation

      • Hideto Takahashi, Yusuke Naito
      Pages 157-181

    6. Role of Drebrin in Synaptic Plasticity

      • Yuko Sekino, Noriko Koganezawa, Toshiyuki Mizui, Tomoaki Shirao
      Pages 183-201

    7. Drebrin in Alzheimer’s Disease

      • Yuta Ishizuka, Kenji Hanamura
      Pages 203-223

    8. Drebrins and Connexins: A Biomedical Perspective

      • Irina V. Majoul, Justus S. Ernesti, Eugenia V. Butkevich, Rainer Duden
      Pages 225-247

    9. Homer, Spikar, and Other Drebrin-Binding Proteins in the Brain

      • Hiroyuki Yamazaki, Tomoaki Shirao
      Pages 249-268

  5. Drebrin in Non-Nervous System

    1. Front Matter

      Pages 269-269
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    2. Role of Drebrin at the Immunological Synapse

      • Vera Rocha-Perugini, Mónica Gordon-Alonso, Francisco Sánchez-Madrid
      Pages 271-280
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Keywords

About this book

This book is the first comprehensive review of drebrin, which plays pivotal roles in various cellular events, via forming unique actin cytoskeletons, including synapse formation and in synaptic function. Particularly the loss of drebrin from dendritic spines is used as a marker of dementia in neurological disorders such as Alzheimer’s disease. Since drebrin was first identified by our group in 1985, many studies of drebrin have been done in various fields, including not only molecular biology, biophysics, cell biology, neuroscience, clinical studies, spermatogenesis, immunology, and cancer metastasis, but others as well. The structure of this book facilitates the understanding of the whole picture of studies on drebrin. The volume begins with a general introduction to drebrin, and then the chapters in the second part provide the basic knowledge for further understanding. The third part examines its function in the nervous system, and the fourth part discusses its function in the non-nervous system. This work will appeal to researchers who are interested in cytoskeletal dynamics at membrane-cytoskeletal interface as well as the number of them who use drebrin as a tool, such as a marker of synaptic function or a disease marker. This volume is kept as concise as possible in order to be understood by readers in diverse scientific disciplines.

Editors and Affiliations

  • Department of Neurobiology and Behavior, Gunma University Graduate School of Medicine, Maebashi, Japan

    Tomoaki Shirao

  • Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Japan

    Yuko Sekino

About the editors

Tomoaki Shirao, MD, PhD

Department of Neurobiology and Behavior
Gunma University Graduate School of Medicine
Gunma, Japan


Yuko Sekino, PhD

Division of Pharmacology
National Institute of Health Sciences
Tokyo, Japan

Bibliographic Information

  • Book Title: Drebrin

  • Book Subtitle: From Structure and Function to Physiological and Pathological Roles

  • Editors: Tomoaki Shirao, Yuko Sekino

  • Series Title: Advances in Experimental Medicine and Biology

  • DOI: https://doi.org/10.1007/978-4-431-56550-5

  • Publisher: Springer Tokyo

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Japan KK 2017

  • Hardcover ISBN: 978-4-431-56548-2Published: 19 September 2017

  • Softcover ISBN: 978-4-431-56817-9Published: 22 August 2018

  • eBook ISBN: 978-4-431-56550-5Published: 31 August 2017

  • Series ISSN: 0065-2598

  • Series E-ISSN: 2214-8019

  • Edition Number: 1

  • Number of Pages: XII, 401

  • Number of Illustrations: 29 b/w illustrations, 82 illustrations in colour

  • Topics: Neurochemistry, Biochemistry, general, Cell Biology, Neurology

  • Industry Sectors: Biotechnology

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