Overview
Based on Japanese research findings in autoimmune liver diseases
Explains how Japanese patients with autoimmune hepatitis form a unique disease population as a result of their genetic background
Presents the latest findings in research and treatment of primary biliary cirrhosis patients, along with new pathological staging criteria
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Table of contents (21 chapters)
Keywords
About this book
Autoimmune Liver Diseases summarizes the recent high-impact research and clinical findings obtained in Japan in the study and treatment of autoimmune liver diseases. Although these disorders are relatively rare, they are recognized as an important group of refractory liver diseases, the most common of which are autoimmune hepatitis (AIH) and primary biliary cirrhosis (PBC). The book therefore comprises two major sections, one dealing with AIH, the other with PBC.
AIH in Japanese patients creates a unique disease population, as its clinical features are different from those of Western patients resulting from the different genetic background of the two patient populations. Also, mouse models of neonatal thymectomy-PD-1 knockout mice, clinical analyses of acute hepatitis-like manifestations, and research findings on IgG4-related autoimmune hepatitis have been reported in Japan and are included in this book. A disease-susceptibility gene specific to Japanese PBC patients has also recently been discovered. Because of the relatively homogeneous population of Japan, analyses conducted with Japanese PBC patients have yielded findings that are highly relevant to the pathogenesis of the disease.
Furthermore, new pathological staging criteria, anti-gp210 antibodies and the basis they provide for improved accuracy of prognosis, treatment with bezafibrate, and the outcomes of living-donor liver transplantation are also presented here. This volume therefore serves as a useful resource not only for hepatologists, but also for researchers, clinical residents, and medical students both in Japan and in other countries.
Editors and Affiliations
Bibliographic Information
Book Title: Autoimmune Liver Diseases
Book Subtitle: Perspectives from Japan
Editors: Hiromasa Ohira
DOI: https://doi.org/10.1007/978-4-431-54789-1
Publisher: Springer Tokyo
eBook Packages: Medicine, Medicine (R0)
Copyright Information: Springer Japan 2014
Hardcover ISBN: 978-4-431-54788-4Published: 02 September 2014
Softcover ISBN: 978-4-431-56171-2Published: 22 September 2016
eBook ISBN: 978-4-431-54789-1Published: 21 August 2014
Edition Number: 1
Number of Pages: VIII, 305
Number of Illustrations: 26 b/w illustrations, 44 illustrations in colour
Topics: Gastroenterology, Hepatology, Internal Medicine
Industry Sectors: Biotechnology, Finance, Business & Banking, Health & Hospitals, Pharma