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Testicular Autoimmunity

A Cause of Male Infertility

  • Masahiro Itoh

About this book

Introduction

This book addresses various aspects of testicular autoimmunity. It has long been suspected that testicular autoimmunity could be one of the causes of idiopathic male infertility. However, it is very difficult to estimate the incidence of testicular autoimmunity in men, as most male patients first realize they are infertile when they start trying to conceive a child, and there is a possibility that their testes may already exhibit the end stage of testicular autoimmunity, in which lymphocytic inflammation and immunoglobulin deposition in their testes subsided long ago and only the spermatogenic disorder remains. Therefore, autopsy or biopsy for testicular tissues in men before the end stage of testicular autoimmunity and investigations using testicular autoimmunity model animals are needed to determine the epidemiology of testicular autoimmunity.

Accordingly, the book discusses “the immunological fragility of testis” with regard to male infertility, reviewing aut
opsy data in men and presenting experimental data using murine models of autoimmune orchitis that has been induced by immunizing with viable syngeneic testicular germ cells alone. Testicular autoimmunity in animals is also discussed. 

In summary, the book provides a wealth of valuable information, not only for researchers who are interested in immunologic male infertility, but also for clinical professionals who treat these patients at hospitals.

Keywords

autoimmune orchitis idiopathic infertility reproductive immunology spermatogenic disturbance testis

Authors and affiliations

  • Masahiro Itoh
    • 1
  1. 1.Department of AnatomyTokyo Medical UniversityShinjyuku-kuJapan

Bibliographic information

  • DOI https://doi.org/10.1007/978-4-431-54460-9
  • Copyright Information Springer Japan 2017
  • Publisher Name Springer, Tokyo
  • eBook Packages Medicine
  • Print ISBN 978-4-431-54459-3
  • Online ISBN 978-4-431-54460-9
  • Buy this book on publisher's site
Industry Sectors
Pharma
Health & Hospitals
Biotechnology