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Chembiomolecular Science

At the Frontier of Chemistry and Biology

  • Conference proceedings
  • © 2013

Overview

Editors:
  1. Masakatsu Shibasaki

    1. Institute of Microbial Chemistry, Tokyo, Japan

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  2. Masamitsu Iino

    1. The University of Tokyo, Department of Pharmacology, Graduate School of Medicine, Bunkyo-ku, Japan

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  3. Hiroyuki Osada

    1. RIKEN Advanced Science Institute, Antibiotics Laboratory, Chemical Biology Core Facility, Wako, Japan

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  • Elucidates new biological mechanisms as potential drug targets

  • Provides new insights from the frontiers of research in biology and chemistry

  • Promotes development of new drug therapies to improve human health

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Table of contents (31 papers)

  1. Chembiomolecular Biology

    1. Visual Screening for the Natural Compounds That Affect the Formation of Nuclear Structures

      • Kaya Shigaki, Kazuaki Tokunaga, Yuki Mihara, Yota Matsuo, Yamato Kojimoto, Hiroaki Yagi et al.
      Pages 183-192

    2. Versatile Orphan Nuclear Receptor NR4A2 as a Promising Molecular Target for Multiple Sclerosis and Other Autoimmune Diseases

      • Shinji Oki, Benjamin J. E. Raveney, Yoshimitsu Doi, Takashi Yamamura
      Pages 193-200

    3. Antiviral MicroRNA

      • Ryota Ouda, Takashi Fujita
      Pages 201-205

    4. Synaptic Function Monitored Using Chemobiomolecular Indicators

      • Masamitsu Iino
      Pages 207-215

  2. Chembiomolecular Medicinal Chemistry

    1. Front Matter

      Pages 217-217
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    2. Practical Catalytic Asymmetric Synthesis of a Promising Drug Candidate

      • Masakatsu Shibasaki
      Pages 219-228

    3. Hunting the Targets of Natural Product-Inspired Compounds

      • Slava Ziegler, Herbert Waldmann
      Pages 229-238

    4. Chemical Approaches for Understanding and Controlling Infectious Diseases

      • Hirokazu Arimoto
      Pages 239-247

    5. Nongenomic Mechanism-Mediated Renal Fibrosis-Decreasing Activity of a Series of PPAR-γ Agonists

      • Hiroyuki Miyachi
      Pages 249-260

    6. Novel Carbohydrate-Based Inhibitors That Target Influenza A Virus Sialidase

      • Mark von Itzstein
      Pages 261-267

    7. Multidrug Efflux Pumps and Development of Therapeutic Strategies to Control Infectious Diseases

      • Kunihiko Nishino
      Pages 269-279

    8. Enzymes as Chemotherapeutic Agents

      • Ronald T. Raines
      Pages 281-291

    9. Mechanism of Action of New Antiinfectious Agents from Microorganisms

      • Nobuhiro Koyama, Hiroshi Tomoda
      Pages 293-300

    10. Correction of RNA Splicing with Antisense Oligonucleotides as a Therapeutic Strategy for a Neurodegenerative Disease

      • Yimin Hua, Kentaro Sahashi, Frank Rigo, Gene Hung, C. Frank Bennett, Adrian R. Krainer
      Pages 301-313

    11. Modulation of Pre-mRNA Splicing Patterns with Synthetic Chemicals and Their Clinical Applications

      • Masatoshi Hagiwara
      Pages 315-319

  3. Back Matter

    Pages 321-325
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Keywords

About this book

At the forefront of life sciences today is the emerging discipline of chembiomolecular science. This new term describes the integration of the frontier fields of chemical biology, chemistry, and pharmacology. Chembiomolecular science aims to elucidate new biological mechanisms as potential drug targets and enhance the creation of new drug therapies. This book comprises the proceedings of the Uehara Memorial Foundation Symposium 2011, which focused on the most recent advances in chembiomolecular science made by leading experts in the field. The book is divided into three main topics. The first is the chemical approach to understanding complex biological systems on a molecular level using chemical compounds as a probe. The second describes the biological approach used to develop new lead drug compounds. The third focuses on the biological system that serves as the potential drug target, the beginning step in the process of developing new drugs. Replete with the latest research, the book will draw the attention of all scientists interested in the synergies between chemistry and biology to elucidate life on a molecular level and to promote drug discovery. Ultimately, the book helps promote the understanding of biological functions at the molecular level and create new pharmaceuticals that can contribute to improving human health.

Editors and Affiliations

  • Institute of Microbial Chemistry, Tokyo, Japan

    Masakatsu Shibasaki

  • The University of Tokyo, Department of Pharmacology, Graduate School of Medicine, Bunkyo-ku, Japan

    Masamitsu Iino

  • RIKEN Advanced Science Institute, Antibiotics Laboratory, Chemical Biology Core Facility, Wako, Japan

    Hiroyuki Osada

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