Harnessing Biological Complexity

An Introduction to Computational Physiology

  • Taishin Nomura
  • Yoshiyuki Asai

Part of the A First Course in “In Silico Medicine” book series (FCISM, volume 1)

Table of contents

  1. Front Matter
    Pages i-x
  2. Taishin Nomura, Yoshiyuki Asai
    Pages 1-9
  3. Taishin Nomura, Yoshiyuki Asai
    Pages 11-81
  4. Taishin Nomura, Yoshiyuki Asai
    Pages 83-124
  5. Taishin Nomura, Yoshiyuki Asai
    Pages 125-194
  6. Taishin Nomura, Yoshiyuki Asai
    Pages 195-216
  7. Back Matter
    Pages 217-222

About this book


The challenge for the biosciences in the twenty-first century is to integrate genome sequencing information into a better understanding of biology, physiology, and human pathology. Such attempts at integration are moving the world toward a new generation of bioscience and bioengineering, where biological, physiological, and pathological information from humans and other living animals can be quantitatively described in silico across multiple scales of time and size and through diverse hierarchies of organization — from molecules to cells and organs, to individuals. To "harness" such complexity, international communities of integrative bioscientists and bioengineers aim to establish frameworks and information infrastructures for describing biological structures and physiological functions on multiple scales of time and space. This textbook includes a public platform to describe physiological functions using mathematical equations and guides the reader to perform mathematical modeling and computer simulations, to combine existing models as well as to create new models. Accessible to biologists, physiologists, and students of the sciences, with illustrative details provided when necessary, this book seeks to achieve a systematic way of harnessing biological complexity. Sharing the databases among communities worldwide will help to find comprehensive answers to all the important questions.


biological complexity computational approaches to biological phenomena integration of biological functions model database modeling and simulating biological dynamics physiome, physiology, multi-physics simulation

Editors and affiliations

  • Taishin Nomura
    • 1
  • Yoshiyuki Asai
    • 2
  1. 1.Mechanical Science and Bioengineering Graduate School of Engineering ScienceOsaka UniversityToyonakaJapan
  2. 2.The Center for Advanced Medical Engineering and InformaticsOsaka UniversityToyonakaJapan

Bibliographic information

  • DOI
  • Copyright Information Springer Japan KK 2011
  • Publisher Name Springer, Tokyo
  • eBook Packages Engineering
  • Print ISBN 978-4-431-53879-0
  • Online ISBN 978-4-431-53880-6
  • Buy this book on publisher's site
Industry Sectors
Materials & Steel
Consumer Packaged Goods