New Trends in the Diagnosis and Therapy of Alzheimer’s Disease

1. Front Matter

   Pages I-VII

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2. Synaptic pathology in the pathogenesis of Alzheimer dementia

   • R. D. Terry, E. Masliah

   Pages 1-8

3. Classification of dementias based on functional morphology

   • K. A. Jellinger, C. Bancher

   Pages 9-39

4. Computed tomography and magnetic resonance imaging in the diagnosis of Alzheimer’s disease

   • F. T. Aichner, S. R. Felber, G. G. Birbamer

   Pages 41-51

5. Diagnostic imaging techniques with special reference to PET

   • W.-D. Heiss

   Pages 53-67

6. Neurochemical investigations in patients with dementia of Alzheimer type and their clinical value

   • L. Frölich, A. Dirr, M. E. Götz, Y. Taneli, J. Thome, K. P. Lesch et al.

   Pages 69-80

7. Different methodological approaches for the construction of a therapy sensitive ADL scale for the assessment of Alzheimer patients

   • M. Stemmler, K.-C. Steinwachs, H. Lehfeld, J. Jentzsch, K. Tritt, F. W. Hulla et al.

   Pages 81-89

8. Trial designs and outcome variables in anti-dementia drug testing

   • M. Panisset, S. Gauthier

   Pages 91-103

9. Cognitive deterioration in old age and in the course of dementia

   • W. D. Oswald, K. Tritt

   Pages 105-113

10. NGF and Alzheimer’s disease: a model for trophic factor therapy in neurodegeneration

    • B. Knüsel, F. Hefti

    Pages 115-130

11. Efficacy of Cerebrolysin® in Alzheimer’s disease

    • E. Ruether, R. Ritter, M. Apecechea, S. Freitag, M. Windisch

    Pages 131-141

12. Back Matter

    Pages 143-151

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Alzheimer´s Disease (AD), the most frequent cause of mental decline in the elderly represents one of the major health problems facing modern society. Despite considerable progress in the clinical diagnosis, epidemiology, structural basis, biochemistry, molecular genetics, and pharmacological aspects of AD, its etiology, molecular backgrounds, and treatment challenges are still poorly understood. This volume based on the 2nd International Symposium of EBEWE Research Initiative in October 1993 in Salzburg, Austria, is conceived as a review of our current knowledge of morphology, diagnostic clinical and imaging techniques, methodological approaches of cognitive assessment, trial designs, outcome variables and possibilities of therapy of AD and other neurodegenerative disorders. The book´s coverage is broad and it should be of interest for investigators, clinicians, and researchers involved in the problems of AD.

• Alzheimer's disease
• Alzheimer´s disease
• PET
• biochemistry
• dementia
• diagnosis
• drug
• epidemiology
• genetics
• magnetic resonance imaging (MRI)
• neurodegenerative disorders
• positron emission tomography (PET)
• research
• therapy

• Ludwig Boltzmann Institute of Clinical Neurobiology, Lainz Hospital, Vienna, Austria

  K. A. Jellinger

• Department of Neurology, Landesnervenklinik, Salzburg, Austria

  G. Ladurner

• Department of Research and Development, Ebewe Pharmaceuticals Ltd., Unterach, Austria

  M. Windisch

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