Advances in Neuroscience and Schizophrenia

1. Front Matter

   Pages I-IX

   PDF

2. Imaging

   1. Front Matter

      Pages 1-1

      PDF

   2. Critical review of PET, SPECT and neuroreceptor studies in schizophrenia

      • T. F. Budinger

      Pages 3-12

   3. MRI and cognitive behavioral function in schizophrenia

      • R. E. Gur

      Pages 13-22

   4. Molecular insights into schizophrenia

      • J. W. Pettegrew, N. J. Minshew

      Pages 23-40

3. Basal ganglia

   1. Front Matter

      Pages 41-41

      PDF

   2. The neostriatal mosaic: multiple levels of compartmental organization

      • C. R. Gerfen

      Pages 43-59

   3. The regulation of subcortical dopamine systems by the prefrontal cortex: interactions of central dopamine systems and the pathogenesis of schizophrenia

      • A. Y. Deutch

      Pages 61-89

   4. The depolarization block hypothesis of neuroleptic action: implications for the etiology and treatment of schizophrenia

      • A. A. Grace

      Pages 91-131

4. Prefrontal cortex

   1. Front Matter

      Pages 133-133

      PDF

   2. NE/DA interactions in prefrontal cortex and their possible roles as neuromodulators in schizophrenia

      • J. P. Tassin

      Pages 135-162

   3. The anatomy of dopamine in monkey and human prefrontal cortex

      • P. S. Goldman-Rakic, M. S. Lidow, J. F. Smiley, M. S. Williams

      Pages 163-177

   4. The catecholaminergic innervation of primate prefrontal cortex

      • D. A. Lewis

      Pages 179-200

5. Back Matter

   Pages 201-203

   PDF

Schizophrenia has been the subject of intense research interest in recent years, as investigators have explored the biological bases for the disorder and for various approaches to its diagnosis and treatment. This volume focuses on three aspects of such recent research connecting basic neuroscience to schizophrenia. In one, Professors Budinger, Gur, and Pettegrew provide critical reviews of brain imaging studies as they relate to cognitive behaviour functions in schizophrenia. In the second, Professors Goldmann-Rakic, Lewis, and Tassin discuss monoamine systems and their varied role in prefontal cortical circuitry and function. In the third, Professors Deutsch, Gerfen, and Grace discuss the structure, organization, and function of the basal ganglia, as they relate to schizophrenia and the mechanisms of neuroleptic action. These papers were presented at an interdisciplinary workshop on the subject at the University of Pittsburgh, in May 1991, and the discussion between the authors and other panelists in basic and clinical sciences are included in this volume as well. The presentation of these diverse approaches in an integrated fashion provides the reader with a unique perspective and a wealth of new questions for future collaborative research.

• PET
• SPECT
• anatomy
• brain
• brain imaging
• cortex
• dopamine
• magnetic resonance imaging (MRI)
• neuroscience
• positron emission tomography (PET)
• receptor
• research
• schizophrenia

• Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, USA

  A. H. Tuma, S. Gershon

• Department of Behavioral Neuroscience, University of Pittsburgh, Pittsburgh, USA

  E. M. Stricker

Policies and ethics