The Nucleolus and Ribosome Biogenesis

  • Asen A. Hadjiolov

Part of the Cell Biology Monographs book series (CELLBIOL, volume 12)

Table of contents

  1. Front Matter
    Pages I-XI
  2. Asen A. Hadjiolov
    Pages 1-4
  3. Asen A. Hadjiolov
    Pages 5-53
  4. Asen A. Hadjiolov
    Pages 54-86
  5. Asen A. Hadjiolov
    Pages 87-110
  6. Asen A. Hadjiolov
    Pages 111-132
  7. Asen A. Hadjiolov
    Pages 133-164
  8. Back Matter
    Pages 197-271

About this book


The nucleolus had consistently attracted the attention of investigators in the fields of cell biology and pathology. Because of its ubiquitous presence in the nucleus of eukaryotic cells, its rapid changes during their life cycle, and its rapid response to noxious agents, this organelle has been the subject of a large number of studies. Yet, the exact function and the very reason for the existence of the nucleolus (the only large cellular structure not delimited by a membrane) remain largely unknown. The ribosomes were discovered relatively late in the study of cells, but due to their crucial involvement in the protein synthesis machinery of all living organisms, the elucidation of their structure and function quickly became one of the major goals of molecular biology. The relatively simple structure of the ribosome strengthens the hope that a full understanding of the structure and function of this organelle in molecular terms is within the reach of contemporary research~ Since each of the rRNA and protein molecules embodied in the ribosome is the product of a distinct gene, studies on the biogenesis of ribosomes expanded rapidly to become a core topic in molecular genetics.


DNA RNA biology cell biology enzymes membrane molecular biology molecular genetics primary structure protein protein synthesis regeneration synthesis transcription

Authors and affiliations

  • Asen A. Hadjiolov
    • 1
  1. 1.Department of Molecular Genetics, Institute of Molecular BiologyBulgarian Academy of SciencesSofiaBulgaria

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag Vienna 1985
  • Publisher Name Springer, Vienna
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-7091-8744-9
  • Online ISBN 978-3-7091-8742-5
  • Series Print ISSN 0172-4665
  • Buy this book on publisher's site
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