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Fortschritte der Chemie organischer Naturstoffe / Progress in the Chemistry of Organic Natural Products

  • Authors
  • D. R. Adams
  • M. Brochwicz-Lewinski
  • A. R. Butler
  • W. Herz
  • H. Falk
  • G. W. Kirby
  • R. E. Moore
  • Ch. Tamm

Table of contents

  1. Front Matter
    Pages I-VII
  2. D. R. Adams, M. Brochwicz-Lewinski, A. R. Butler
    Pages 1-186
  3. Back Matter
    Pages 187-214

About this book

Introduction

In order to make further progress in elucidating the mechanism of NOS catalysis it will be essential to throw light on the interaction between the enzyme and its substrate. An understanding of the catalytic site will also assist the development of therapeutically important NOS inhibitors. In particular. it will be useful to uncover any differences that exist between the substrate binding sites of the three NOS isozymes which might be exploited for the development of isoform selective NOS inhibitors. A comparison of NOS to other Arg-binding proteins has shown no significant sequence homology (159). Moreover, the lack of a 3D structure and absence of significant sequence homology between the NOS oxygenase domain and known cytochromes P450 has made it difficult to identify residues and construct a model of the distal heme pocket responsible for substrate binding. However, a number of groups are currently working towards crystallisation of the separate NOS reductase and oxygenase domains of the three isoforms for X-ray diffraction studies; the first X-ray structure is likely to be forthcoming within a matter of months. * The results of these studies are expected to resolve many of the uncertainties surrounding the structure of the NOS catalytic site. Preliminary X-ray diffraction analysis of CPR from rat liver has already been reported by MASTERS et al. (524) and the future emergence of a detailed structure for this protein should throw light on the structure and function of the NOS reductase domain.

Keywords

NO activity NO release Nitric oxide Stickoxid biochemistry chemistry natural product polymer

Editors and affiliations

  • W. Herz
    • 1
  • H. Falk
    • 2
  • G. W. Kirby
    • 3
  • R. E. Moore
    • 4
  • Ch. Tamm
    • 5
  1. 1.Department of ChemistryThe Florida State UniversityTallahasseeUSA
  2. 2.Institut für ChemieJohannes-Kepler-UniversitätLinzAustria
  3. 3.Chemistry DepartmentThe University of GlasgowGlasgowScotland
  4. 4.Department of ChemistryUniversity of Hawaii at ManoaHonoluluUSA
  5. 5.Institut für Organische Chemie der Universität BaselBaselSwitzerland

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-7091-6351-1
  • Copyright Information Springer-Verlag/Wien 1999
  • Publisher Name Springer, Vienna
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-7091-7305-3
  • Online ISBN 978-3-7091-6351-1
  • Series Print ISSN 0071-7886
  • Buy this book on publisher's site
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