Ras Superfamily Small G Proteins: Biology and Mechanisms 1

General Features, Signaling

  • Alfred Wittinghofer

Table of contents

  1. Front Matter
    Pages i-xiv
  2. Ras Superfamily, General Topics

    1. Front Matter
      Pages 1-1
    2. Ana M. Rojas, Alfonso Valencia
      Pages 3-23
    3. Jacqueline Cherfils
      Pages 51-63
    4. Klaus Aktories, Gudula Schmidt
      Pages 65-97
    5. Bingying Zhou, Adrienne D. Cox
      Pages 99-131
  3. Ras Subfamily

    1. Front Matter
      Pages 133-133
    2. Tikvah K. Hayes, Jeran K. Stratford, Andrea Wang-Gillam, Channing J. Der
      Pages 157-171
    3. Björn Papke, Malte Schmick, Nachiket Vartak, Philippe I. H. Bastiaens
      Pages 173-188
    4. Yong Zhou, John F. Hancock
      Pages 189-210
    5. Carmen Guerra, Mariano Barbacid
      Pages 211-231
    6. Willem-Jan Pannekoek, Johannes L. Bos
      Pages 233-255
    7. Brian O. Bodemann, Michael A. White
      Pages 257-279
    8. Christopher B. Marshall, Mohammad T. Mazhab-Jafari, Vuk Stambolic, Mitsuhiko Ikura
      Pages 281-324
  4. Rho Subfamily

    1. Front Matter
      Pages 325-325
    2. Si-Cai Zhang, Kazem Nouri, Ehsan Amin, Mohamed S. Taha, Hossein Nakhaeizadeh, Saeideh Nakhaei-Rad et al.
      Pages 327-340
    3. Barbara Borda-d’Agua, Elvira Infante, Philippe Riou, Virginia Tajadura, Anne J. Ridley
      Pages 341-361
    4. Jon W. Erickson, Marc A. Antonyak, Reina Fuji, Richard A. Cerione
      Pages 421-438
  5. Back Matter
    Pages 439-445

About this book


This first of two volumes provides a general overview of the genetics, structure, mechanism and regulation of the Ras superfamily proteins and describes in detail the signaling pathways and processes regulated by specific members of this family. The focus of this first volume is on the Rho and Ras subfamily of small G proteins.

Renowned scientists provide insights into the biochemistry of the classical and non-classical small G-protein family members, their spatio-temporal regulation, their effectors and their roles in health and disease. Together with Volume 2, this book provides a comprehensive and state-of-the-art work on small G-proteins (GTPases). It is intended for graduates and professors in biochemistry and cell biology already working on small G-proteins (small GTPases), but also offers an extremely valuable resource for those readers who are new to the field.


GTPases, GTP-binding cell signaling molecular switch protein imaging spatiotemporal regulation vesicular traffic

Editors and affiliations

  • Alfred Wittinghofer
    • 1
  1. 1.Max-Planck-Institute of Molecular PhysiologyDortmundGermany

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