Anticarbohydrate Antibodies

From Molecular Basis to Clinical Application

  • Paul Kosma
  • Sven Müller-Loennies

Table of contents

  1. Front Matter
    Pages i-xiii
  2. François-Xavier Theillet, Pierre Chassagne, Muriel Delepierre, Armelle Phalipon, Laurence A. Mulard
    Pages 1-36
  3. Ryan J. Blackler, Sven Müller-Loennies, Lore Brade, Paul Kosma, Helmut Brade, Stephen V. Evans
    Pages 75-120
  4. David R. Bundle, Casey Costello, Corwin Nycholat, Tomasz Lipinski, Robert Rennie
    Pages 121-145
  5. Renate Kunert
    Pages 147-160
  6. Rick M. Maizels, James P. Hewitson
    Pages 161-180
  7. Mark Agostino, William Farrugia, Mauro S. Sandrin, Andrew M. Scott, Elizabeth Yuriev, Paul A. Ramsland
    Pages 203-228
  8. Somdutta Saha, Anastas Pashov, Behjatolah Monzavi-Karbassi, Ann Marie Kieber-Emmons, Akashi Otaki, Ramachandran Murali et al.
    Pages 229-254
  9. Ulrika Westerlind, Horst Kunz
    Pages 255-281
  10. Ola Blixt, Irene Boos, Ulla Mandel
    Pages 283-306
  11. Robert J. Woods, Austin B. Yongye
    Pages 361-383
  12. Filipa Marcelo, F. Javier Cañada, Jesús Jiménez-Barbero
    Pages 385-402
  13. Roger MacKenzie, Sven Müller-Loennies
    Pages 403-429
  14. Back Matter
    Pages 431-438

About this book

Introduction

Anticarbohydrate Antibodies – from molecular basis to clinical application compiles current knowledge on the immunological recognition of carbohydrates by the adaptive immune system from a molecular perspective providing fundamental insight needed for advancing clinically relevant diagnostics and therapeutic applications. Based on significant progress in the fields of glycoimmunology and structural biology in recent years, the book comprehensively reviews the state-of-the-art in defining the key elements of carbohydrate recognition by antibodies, the molecular mimicry of carbohydrate epitopes as well as the molecular features leading to specific and relaxed binding modes. Backed-up by a combination of modern technologies to elucidate structural details of carbohydrate-antibody interactions, biomedically important carbohydrate antigens from viral, bacterial, parasite, insect and tumor cells have been analyzed in in-depth reviews written by well-known experts in the field. Fundamental knowledge of these molecular mechanisms eventually provides a rational basis to improve efficacy of carbohydrate-based vaccines and to further refine diagnostic tools in detection of pathogens and malignant cells.

Keywords

antibodies anticarbohydrate antibodies immune response protein-carbohydrate interaction vaccines

Editors and affiliations

  • Paul Kosma
    • 1
  • Sven Müller-Loennies
    • 2
  1. 1., Department für ChemieUniversität für Bodenkultur WienWienAustria
  2. 2., Zentrum für Medizin und BiowissenschafteForschungszentrum BorstelBorstelGermany

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-7091-0870-3
  • Copyright Information Springer-Verlag/Wien 2012
  • Publisher Name Springer, Vienna
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-3-7091-0869-7
  • Online ISBN 978-3-7091-0870-3
  • About this book
Industry Sectors
Biotechnology
Pharma