SialoGlyco Chemistry and Biology I

1. Front Matter

   Pages i-ix

   PDF

2. Functions and Biosynthesis of O-Acetylated Sialic Acids

   • Chitra Mandal, Reinhard Schwartz-Albiez, Reinhard Vlasak

   Pages 1-30

3. Why Is N-Glycolylneuraminic Acid Rare in the Vertebrate Brain?

   • Leela R. L. Davies, Ajit Varki

   Pages 31-54

4. Polysialic Acid in Brain Development and Synaptic Plasticity

   • Herbert Hildebrandt, Alexander Dityatev

   Pages 55-96

5. UDP-GlcNAc 2-Epimerase/ManNAc Kinase (GNE): A Master Regulator of Sialic Acid Synthesis

   • Stephan Hinderlich, Wenke Weidemann, Tal Yardeni, Rüdiger Horstkorte, Marjan Huizing

   Pages 97-137

6. CMP-Sialic Acid Synthetase: The Point of Constriction in the Sialylation Pathway

   • Melanie Sellmeier, Birgit Weinhold, Anja Münster-Kühnel

   Pages 139-167

7. Natural Antibodies Against Sialoglycans

   • Nadezhda Shilova, Margaret E. Huflejt, Marko Vuskovic, Polina Obukhova, Maksim Navakouski, Nailya Khasbiullina et al.

   Pages 169-181

8. Structure and Function of Mammalian Sialidases

   • Eugenio Monti, Taeko Miyagi

   Pages 183-208

9. Back Matter

   Pages 209-211

   PDF

The series Topics in Current Chemistry presents critical reviews of the present and future trends in modern chemical research. The scope of coverage is all areas of chemical science including the interfaces with related disciplines such as biology, medicine and materials science. The goal of each thematic volume is to give the non-specialist reader, whether in academia or industry, a comprehensive insight into an area where new research is emerging which is of interest to a larger scientific audience. Each review within the volume critically surveys one aspect of that topic and places it within the context of the volume as a whole. The most significant developments of the last 5 to 10 years are presented using selected examples to illustrate the principles discussed. The coverage is not intended to be an exhaustive summary of the field or include large quantities of data, but should rather be conceptual, concentrating on the methodological thinking that will allow the non-specialist reader to understand the information presented. Contributions also offer an outlook on potential future developments in the field. Review articles for the individual volumes are invited by the volume editors. Readership: research chemists at universities or in industry, graduate students

• SIGLEC4 Antagonists
• Sialic acids
• Sialoglycoconjugates
• Sialoside Arrays
• lectin microarray

• Institute for Cellular Chemistry, Hannover, Germany

  Rita Gerardy-Schahn

• Lille University of Science and Technology, Villeneuve d'Ascq Cedex, France

  Philippe Delannoy

• Institute for Glycomics, Griffith University, Southport, Australia

  Mark von Itzstein

Policies and ethics