Predictive Methods in Percutaneous Absorption

  • Gary P. Moss
  • Darren R. Gullick
  • Simon C. Wilkinson

Table of contents

  1. Front Matter
    Pages i-xv
  2. Gary P. Moss, Darren R. Gullick, Simon C. Wilkinson
    Pages 1-24
  3. Gary P. Moss, Darren R. Gullick, Simon C. Wilkinson
    Pages 25-42
  4. Gary P. Moss, Darren R. Gullick, Simon C. Wilkinson
    Pages 43-63
  5. Gary P. Moss, Darren R. Gullick, Simon C. Wilkinson
    Pages 65-89
  6. Gary P. Moss, Darren R. Gullick, Simon C. Wilkinson
    Pages 91-102
  7. Gary P. Moss, Darren R. Gullick, Simon C. Wilkinson
    Pages 103-115
  8. Gary P. Moss, Darren R. Gullick, Simon C. Wilkinson
    Pages 117-139
  9. Gary P. Moss, Darren R. Gullick, Simon C. Wilkinson
    Pages 141-158
  10. Gary P. Moss, Darren R. Gullick, Simon C. Wilkinson
    Pages 159-179
  11. Gary P. Moss, Darren R. Gullick, Simon C. Wilkinson
    Pages 181-192
  12. Back Matter
    Pages 193-199

About this book

Introduction

This book sheds new light on the development and use of quantitative models to describe the process of skin permeation. It critically reviews the development of quantitative predictive models of skin absorption and discusses key recommendations for model development. Topics presented include an introduction to skin physiology; the underlying theories of skin absorption; the physical laboratory-based processes used to generate skin absorption data, which is in turn used to construct mathematical models describing the skin permeation process; algorithms of skin permeability including quantitative structure-activity (or permeability) relationships (QSARs or QSPRs); relationships between permeability and molecular properties; the development of formulation-focused approaches to models of skin permeability prediction; the use of artificial membranes, e.g. polydimethylsiloxane as alternatives to mammalian skin; and lastly, the use of novel Machine Learning methods in developing the next generation of predictive skin permeability models.

The book will be of interest to all researchers in academia and industry working in pharmaceutical discovery and development, as well as readers from the field of occupational exposure and risk assessment, especially those whose work involves agrochemicals, bulk chemicals and cosmetics.

Keywords

Artificial membranes Diffusion modelling Percutaneous absorption Quantitative structure-activity relationships (QSARs) Skin permeability Transdermal drug delivery

Authors and affiliations

  • Gary P. Moss
    • 1
  • Darren R. Gullick
    • 2
  • Simon C. Wilkinson
    • 3
  1. 1.The School of PharmacyKeele UniversityKeeleUnited Kingdom
  2. 2.College of PharmacyUniversity of GeorgiaAthensUSA
  3. 3.Medical Toxicology Centre Institute of Cellular MedicineNewcastle UniversityNewcastle upon TyneUnited Kingdom

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-662-47371-9
  • Copyright Information Springer-Verlag Berlin Heidelberg 2015
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-3-662-47370-2
  • Online ISBN 978-3-662-47371-9
  • About this book
Industry Sectors
Chemical Manufacturing
Biotechnology
Consumer Packaged Goods
Pharma