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Behavioral Neurobiology of Huntington's Disease and Parkinson's Disease

  • Hoa Huu Phuc Nguyen
  • M. Angela Cenci

Part of the Current Topics in Behavioral Neurosciences book series (CTBN, volume 22)

Table of contents

  1. Front Matter
    Pages i-xiii
  2. Rhia Ghosh, Sarah J. Tabrizi
    Pages 3-31
  3. Henry J. Waldvogel, Eric H. Kim, Lynette J. Tippett, Jean-Paul G. Vonsattel, Richard LM Faull
    Pages 33-80
  4. Rebecca A. G. De Souza, Blair R. Leavitt
    Pages 81-100
  5. Simon P. Brooks, Stephen B. Dunnett
    Pages 101-133
  6. João Casaca Carreira, Ali Jahanshahi, Dagmar Zeef, Ersoy Kocabicak, Rinske Vlamings, Stephan von Hörsten et al.
    Pages 135-147
  7. Xiao-Jiang Li, Shihua Li
    Pages 149-160
  8. Ladislav Mrzljak, Ignacio Munoz-Sanjuan
    Pages 161-201
  9. Susanne A. Schneider, Jose A. Obeso
    Pages 205-220
  10. Anke Van der Perren, Chris Van den Haute, Veerle Baekelandt
    Pages 271-301
  11. Guillaume Daniel, Darren J. Moore
    Pages 331-368
  12. Lisa Fellner, Gregor K. Wenning, Nadia Stefanova
    Pages 369-393
  13. Back Matter
    Pages 395-397

About this book

Introduction

Motor dysfunction and cognitive impairment are major symptoms in both Huntington’s Disease (HD) and Parkinson’s Disease (PD). A breakthrough in HD research occurred in 1993, with the identification of the gene causing this devastating monogenetic illness. Since 1996, several genes were reported to cause familial forms of PD. Following these genetic discoveries, a variety of genetic disease models were generated, providing completely novel opportunities to explore the neurobiological basis of HD and PD. Genetic models allow us to study the earliest manifestations of the diseases both behaviorally and neuropathologically, and provide tools to probe molecular pathways of neurodegeneration. Additionally, neurotoxic animal models allow us to reproduce neurochemical and cellular events of great pathophysiological importance. In the PD field, neurotoxic animal models remain the preferred option to reproduce symptomatic features of the human disease that are responsive to dopaminergic pharmacotherapies. In addition, neurotoxic PD models are often used to investigate pathways of mitochondrial dysfunction, oxidative stress, and neuroinflammation. This book provides up-to-date reviews on current animal models of both HD and PD. These animal models are essential to investigate links between the pathobiology and the behavioral abnormalities associated with these disorders.

Keywords

Huntington LRRK2 Parkin Pink-1 Polyglutamine animal models

Editors and affiliations

  • Hoa Huu Phuc Nguyen
    • 1
  • M. Angela Cenci
    • 2
  1. 1.Institute of Medical Genetics and Applied GenomicsUniversity of TuebingenTübingenGermany
  2. 2.Dept of Experimental Medical ScienceLund UniversityLundSweden

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-662-46344-4
  • Copyright Information Springer-Verlag Berlin Heidelberg 2015
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Biomedical and Life Sciences
  • Print ISBN 978-3-662-46343-7
  • Online ISBN 978-3-662-46344-4
  • Series Print ISSN 1866-3370
  • Series Online ISSN 1866-3389
  • Buy this book on publisher's site
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