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Neuronal Death by Accident or by Design

  • Christopher E. Henderson
  • Douglas R. Green
  • Jean Mariani
  • Yves Christen

Part of the Research and Perspectives in Neurosciences book series (NEUROSCIENCE)

Table of contents

  1. Front Matter
    Pages I-XI
  2. O. Terradillos, X. Roucou, S. Da Cruz, B. Sanchez, J.-C. Martinou
    Pages 27-32
  3. C. Raoul, G. Ugolini, A. Estevez, B. Pettmann, C. E. Henderson
    Pages 33-45
  4. G. V. Putcha, M. Deshmukh, E. M. Johnson Jr.
    Pages 47-60
  5. C.-Y. Kuan, R. A. Flavell, P. Rakic
    Pages 75-88
  6. F. Selimi, A. Campana, J. Bakouche, A. Lohof, M. W. Vogel, J. Mariani
    Pages 109-135
  7. Back Matter
    Pages 153-154

About these proceedings

Introduction

Four chapters represent the intense current effort to understand the way in which the mitochondrion controls the activation of the final stages of cell death. Another four articles attack the problem from the other side. How do specific insults in particular human or mouse neuro-degenerative diseases translate into mechanisms that will not only allow us to better understand what is happening in these patients but also, with luck, allow for development of more efficient and specific drugs in the future? Firstly, the concept of a central common cell death pathway, originally derived from studies on the nematode, has been an outstanding productive paradigm in bringing together different strands of research. Secondly, truly striking links have been made between results obtained in the culture dish (or even cell-free systems) and the diseased human brain.

Keywords

Huntingdon's Disease Neurodegeneration Parkinson Parkinson's Disease apoptosis motoneurons neuronal death neurons programmed cell death regulation

Editors and affiliations

  • Christopher E. Henderson
    • 1
  • Douglas R. Green
    • 2
  • Jean Mariani
    • 3
  • Yves Christen
    • 4
  1. 1.INSERM U.382 — IBDM (CNRS — INSERM — Univ. Méditerranée)Marseille Cedex 09France
  2. 2.Division of Cellular ImmunologyLa Jolla Institute for Allergy and ImmunologySan DiegoUSA
  3. 3.Institut des Neurosciences, UMR 7624CNRS et Université Pierre et Marie CurieParisFrance
  4. 4.Pour la Recherche ThérapeutiqueFondation IPSENParis Cedex 16France

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-662-04333-2
  • Copyright Information Springer-Verlag Berlin Heidelberg 2001
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-07517-9
  • Online ISBN 978-3-662-04333-2
  • Series Print ISSN 0945-6082
  • Buy this book on publisher's site
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