Recent Trends in Molecular Recognition

1. Front Matter

   Pages I-XIII

   PDF

2. Designing Transition Metal Complexes for Molecular Recognition in Synthetic Transformations

   • B. M. Trost

   Pages 1-24

3. REDOR NMR of Biological Solids: From Protein Binding Sites to Bacterial Cell Walls

   • J. Schaefer

   Pages 25-52

4. Molecular and Dendritic Receptors for Small Biomolecules

   • F. Diederich

   Pages 53-80

5. Molecular Recognition of DNA by Ecteinascidin 743

   • B. M. Moore II, F. C. Seaman, L. H. Hurley

   Pages 81-95

6. New Tools for Drug Design Based on Protein Ligand Recognition Principles

   • G. Klebe

   Pages 97-118

7. Sequence-Specific Recognition of DNA and Control of Gene Expression by Oligonucleotide-Intercalator Conjugates

   • C. Hélène, C. Giovannangeli, J.-S. Sun, T. Garestier

   Pages 119-133

8. Combinatorial Nucleic Acid Libraries: The New World of Aptamers and Ribozymes

   • M. Famulok

   Pages 135-149

9. Sequence Specific Recognition of Double Stranded DNA by Peptide Nucleic Acid

   • P. E. Nielsen

   Pages 151-167

10. Solid Phase Libraries of Glycopeptide Templates in the Study of Complex Oligosaccharide-Receptor Interactions

    • M. Meldal, P. M. StHilaire, K. Bock

    Pages 169-182

11. The Molecular Recognition of Saccharides and Glycoprotein-Inspired Materials

    • L. L. Kiessling

    Pages 183-212

12. Self-Organized Autocatalytic Chemical Networks and Molecular Ecosystems: Do They Provide the Experimental Tools for Modeling the Transition from Inanimate to Animate Chemistry?

    • M. R. Ghadiri

    Pages 213-238

13. Back Matter

    Pages 239-246

    PDF

Reasoning in terms of molecular recognition may be traced back to Emil Fischer, who practiced the art of chemistry at Humboldt University in Prussian Berlin a century ago. Today, it is clearly recognized that molecular recognition impacts and determines all life processes. It has become a key research field in both chemistry and biology and the emerging interface of what now is being called "chemical biology". The technological advances derived from this knowledge are particularly important, diverse, and directly evident in the pharmaceutical industry. Under the auspices of the Ernst Schering Research Foundation, a workshop held in Berlin in February 1998 addressed novel basic developments of potential relevance to drug research efforts. A balance of timely research topics in molecular recognition is presented in the lectures delivered by a multidisciplinary international panel of renowned scholars and documented in this volume.

• DNA
• Nucleotide
• Oligosaccharid
• biology
• biomolecule
• chemistry
• drug
• drug design
• drug research
• gene expression
• nucleic acid
• pharmaceutical industry
• protein
• receptor
• research

• Laboratorium für Organische Chemie, Swiss Federal Institute of Technology, Zürich, Switzerland

  F. Diederich

• Department of Pharmaceutical Chemistry III, Research Laboratories of Schering AG, Berlin, Germany

  H. Künzer

Policies and ethics