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  • Conference proceedings
  • © 1992

Molecular Aspects of Chemotherapy

Proceedings of the Third International Symposium on Molecular Aspects of Chemotherapy Gdańsk, Poland June 19–21, 1991

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Table of contents (17 papers)

  1. Front Matter

    Pages I-VIII
  2. New Methods in Molecular Shape Analysis to Identify and Characterize Active Conformations

    • B. J. Burke, K. Rowberg, M. G. Cardozo, M. G. Koehler, A. J. Hopfinger
    Pages 23-40
  3. Cyclic Nucleotide Metabolism as a Target in Chemotherapy

    • B. Jastorff, E. Maronde, M. X. P. van Bemmelen, M. Zorn, R. Störmann
    Pages 73-104
  4. Resistance to Anthracyclines in Multidrug Resistant Cells. Role of the Membrane Transport

    • A. Garnier-Suillerot, F. Frezard, J. Tarasiuk
    Pages 105-117
  5. Tumor Necrosis Factor: Mechanism of Action and its Potential for Anticancer Therapy

    • W. Fiers, R. Beyaert, P. Brouckaert, E. Decoster, D. De Valck, B. Everaerdt et al.
    Pages 119-125
  6. Exploitation of Peptide Transport Systems in the Design of Antimicrobial Agents

    • D. R. Tyreman, M. W. Smith, G. M. Payne, J. W. Payne
    Pages 127-142
  7. Inhibitors of 2,3-Oxidosqualene-Lanosterol Cyclase as Antifungal Agents

    • S. Jolidon, A. Polak-Wyss, P. G. Hartman, P. Guerry
    Pages 143-152
  8. The Use of the 3-Dimensional Structures of Rhinoviruses in the Design of Antiviral Agents

    • G. D. Diana, A. M. Treasurywala, T. R. Bailey, R. C. Oglesby
    Pages 153-162
  9. 2′3′Dideoxy-3′Thiacytidine (SddC) as an Anti-Human Hepatitis B Virus (HBV) and Anti-Human Immunodeficiency Virus (HIV) Agent

    • Y-C. Cheng, C-N. Chang, S-L. Doong, G. E. Dutschman, C-H. Tsai, E. A. Murphy et al.
    Pages 231-238
  10. Back Matter

    Pages 271-279

About this book

While serendipity and random screening continue to fulfil a significant role in the search for new drugs, current remarkable advances in molecular biology and genetics are dictating to a profound extent the approaches employed in their development. Increasing attention is being devoted to investigations of the mechanisms of action of existing drugs, and the sources of undesired side effects, at the molecular level. The information so derived is now extensively applied, with the aid of broad inter­ disciplinary approaches, both theoretical and experimental, to improvements in existing drugs, and the rational design of new ones. The foregoing comprised the subject matter of the 3rd Inter­ national Symposium on "Molecular Aspects of Chemotherapy", under the auspices of the International Society of Chemotherapy, and organized by the Committee on Drug Research, Polish Academy of Sciences, and the Department of Biotechnology and Biochemistry, Technical University of Gdansk. This volume includes the texts of the review lectures presented by invited participants on up-to-date achievements, and future perspectives, in molecular mechanisms of inhibition of cellular functions and metabolism, with emphasis on the design and mechanisms of action of chemotherapeutic agents for treatment of bacterial, neoplastic, viral and parasitic diseases. From the Contents, it will be seen that the range of disciplines represented was a broad one, including theoretical and experimental chemists, physicists, molecular biologists, biochemists, enzymologists, virologists, tumour biologists. Plenary sessions were supple­ mented by several poster sessions.

Editors and Affiliations

  • Polish Academy of Sciences, University of Warsaw, Warsaw, Poland

    David Shugar

  • Institute of Biochemistry & Biophysics, Polish Academy of Science, Warszawa, Poland

    David Shugar

  • Department of Biophysics, Institute of Experimental Physics, University of Warsaw, Warszawa, Poland

    David Shugar

  • Nencki Institute of Experimental Biology, Polish Academy of Sciences, Warszawa, Poland

    Wojciech Rode

  • Department of Pharmaceutical Technology & Biochemistry, Technical University of Gdańsk, Gdańsk, Poland

    Edward Borowski

Bibliographic Information

  • Book Title: Molecular Aspects of Chemotherapy

  • Book Subtitle: Proceedings of the Third International Symposium on Molecular Aspects of Chemotherapy Gdańsk, Poland June 19–21, 1991

  • Editors: David Shugar, Wojciech Rode, Edward Borowski

  • DOI: https://doi.org/10.1007/978-3-662-02740-0

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 1992

  • Softcover ISBN: 978-3-662-02742-4Published: 14 December 2012

  • eBook ISBN: 978-3-662-02740-0Published: 09 March 2013

  • Edition Number: 1

  • Number of Pages: VIII, 279

  • Number of Illustrations: 110 b/w illustrations

  • Additional Information: Jointly published with Polish Scientific Publishers, Warsaw

  • Topics: Cell Biology, Biochemistry, general, Oncology

  • Industry Sectors: Biotechnology, Pharma

Buy it now

Buying options

eBook USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access