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The Mechanism of Action of Androgens

  • Book
  • © 1977

Overview

Authors:
  1. W. Ian P. Mainwaring

    1. Androgen Physiology Department, Imperial Cancer Research Fund, London, Great Britain

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Part of the book series: Monographs on Endocrinology (ENDOCRINOLOGY, volume 10)

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Table of contents (24 chapters)

  1. Front Matter

    Pages I-XI
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  2. Introduction

    1. Introduction

      • W. Ian P. Mainwaring
      Pages 1-4

  3. A Contemporary Model for the Mechanism of Action of Androgens

    1. Front Matter

      Pages 5-5
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    2. Definitions

      • W. Ian P. Mainwaring
      Pages 6-7

    3. The Model for the Mechanism of Action of Androgens

      • W. Ian P. Mainwaring
      Pages 8-9

    4. Experimental Support for the Model

      • W. Ian P. Mainwaring
      Pages 10-15

    5. Limitations of the Model of Androgen Action

      • W. Ian P. Mainwaring
      Pages 16-20

    6. Conclusions

      • W. Ian P. Mainwaring
      Pages 21-21

  4. The Metabolism of Androgens in Relation to Their Mechanism of Action

    1. Front Matter

      Pages 23-24
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    2. Relative Biological Activities of Testosterone and Its Metabolites

      • W. Ian P. Mainwaring
      Pages 25-28

    3. General Comments on the Metabolism of Androgens

      • W. Ian P. Mainwaring
      Pages 29-31

    4. Developmental Aspects of the Metabolism of Testosterone

      • W. Ian P. Mainwaring
      Pages 32-37

    5. Androgenic Responses Not Mediated by 5α-dihydrotestosterone

      • W. Ian P. Mainwaring
      Pages 38-39

    6. Interconversion of Steroid Hormones

      • W. Ian P. Mainwaring
      Pages 40-41

    7. Conclusions

      • W. Ian P. Mainwaring
      Pages 42-42

  5. Initial Events in the Mechanism of Action of Androgens

    1. Front Matter

      Pages 43-43
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    2. The Uptake, Retention, and Release of Androgens: Studies on Rat Ventral Prostate Gland

      • W. Ian P. Mainwaring
      Pages 44-77

    3. The Binding of Androgens in Other Target Cells

      • W. Ian P. Mainwaring
      Pages 78-91

    4. Initial Biochemical Events Stimulated by Androgens

      • W. Ian P. Mainwaring
      Pages 92-96

    5. Conclusions

      • W. Ian P. Mainwaring
      Pages 97-97
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Keywords

About this book

My introduction to androgens was neither auspicious nor impressive. I was sitting my viva voce examination for a degree in physiology and had haltingly intimated to my examiner (name decorously withheld) that I intended to pursue a career in re­ search. "On what topic?" was the reply. I had been deeply impressed by the work of C. Huggins and C. V. Hodges (Cancer Res. 1, 293, 1941) on the dramatic arrest of canine prostatic hyperplasia by the administration of stilboestrol. With some en­ thusiasm, I responded, "On steroid hormones, because I am struck by the profound effects that may be achieved by relatively small numbers of molecules. " The examiner sank into deep contemplation before replying, "Young man, have you considered go­ ing into teaching?" Suitably chastened, I finally began my research career investigating the effects of steroids on the nucleic acid metabolism of experimental tumours and on the process cells. Reaching an impasse in this work, I mentioned one of senescence in animal day to Dr. G. F. Marrian that, somewhat surprisingly, we had no understanding of the fundamental mechanism of action of steroid hormones, especially the androgens. me to tackle this problem, particularly since exciting new insights He encouraged were then being made into the interaction of radioactively labelled oestradiol-l?,8 with such tissues as rat uterus.

Authors and Affiliations

  • Androgen Physiology Department, Imperial Cancer Research Fund, London, Great Britain

    W. Ian P. Mainwaring

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