Medullary Thyroid Carcinoma

1. Front Matter

   Pages I-IX

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2. Biological Aspects of Medullary Thyroid Carcinoma

   1. Regulation of Calcitonin Secretion and Calcitonin Gene Expression

      • F. Raue, A. Zink, H. Scherübl

      Pages 1-18

   2. Pathology of Sporadic and Hereditary Medullary Thyroid Carcinoma

      • S. Schröder, K. Holl, B. C. Padberg

      Pages 19-45

   3. Epidemiology of Medullary Thyroid Carcinoma

      • F. Raue

      Pages 47-54

3. Clinical and Diagnostic Aspects of Medullary Thyroid Carcinoma

   1. Tumor Markers for the Medullary Thyroid Carcinoma

      • A. Grauer, E. Blind

      Pages 55-89

   2. Sporadic Medullary Thyroid Carcinoma: Clinical Features and Diagnosis

      • R. Ziegler

      Pages 91-104

   3. Screening for MEN 2 with Biochemical and Genetic Markers

      • M. F. Robinson, R. F. Gagel, F. Raue

      Pages 105-123

   4. Imaging Methods for Medullary Thyroid Cancer

      • C. Reiners

      Pages 125-145

4. Therapeutic Procedure in Medullary Thyroid Carcinoma

   1. Surgical Strategies and Methods for the Treatment of Metastasizing Medullary Thyroid Carcinoma

      • H. J. Buhr, F. Kallinowski, C. Herfarth

      Pages 147-165

   2. Surgical Management of MEN 2

      • H. Dralle, G. F. W. Scheumann, J. Kotzerke, E. G. Brabant

      Pages 167-195

   3. Postsurgical Follow-Up and Management

      • F. Raue

      Pages 197-211

5. Back Matter

   Pages 213-216

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Medullary Thyroid Carcinoma is a rare thyroid tumor originating from neural crest cells, the C-cell that implies several special features, secretion of different neuroendocrine markers, association with other endocrine tumors and familial appearance. The familial variant of medullary thyroid carcinoma allows an early detection by biochemical and genetic testing. At that stage acceptable surgical treatment will cure the patient. The sporadic form of medullary thyroid carcinoma will be diagnosed in a progressive stage, but adequate surgical procedure can cure these patients too. Long term survival depends on stage, age, sex, and variant of the disease and seems to be as good as in other differentiated thyroid cancers.

• Calcitonin
• Karzinom
• Medullary Thyroid Carcinoma
• Medulläres Schilddrüsenkarzinom
• Multiple Endocrine Neoplasia Type 2
• Multiple endocrine Neoplasie Typ 2
• cancer
• carcinoma
• epidemiology
• imaging
• imaging techniques
• pathology
• screening
• tumor

• Abteilung Innere Medizin I — Endokrinologie und Stoffwechsel, Klinikum, Ruprecht Karls-Universität Heidelberg, Heidelberg, Germany

  Friedhelm Raue

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