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Chemical Recognition in Biology

  • Book
  • © 1980

Overview

Editors:
  1. F. Chapeville

    1. CNRS, Inst. de recherche en biologie moléculaire, Université Paris VII, Paris Cedex 05, France

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  2. A.-L. Haenni

    1. CNRS, Inst. de recherche en biologie moléculaire, Université Paris VII, Paris Cedex 05, France

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Table of contents (31 chapters)

  1. Front Matter

    Pages I-XI
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  2. Recognition of Ligands — Enzymic Catalysis

    1. Front Matter

      Pages 1-1
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    2. What Everyone Wanted to Know About Tight Binding and Enzyme Catalysis, but Never Thought of Asking

      • W. P. Jencks
      Pages 3-25

    3. The Cytochromes C: Paradigms for Chemical Recognition

      • M. D. Kamen
      Pages 26-37

    4. Recognition of Ligands by Haem Proteins

      • M. F. Perutz
      Pages 38-42

    5. Influences of Solvent Water on the Transition State Affinity of Enzymes, Protein Folding, and the Composition of the Genetic Code

      • R. Wolfenden
      Pages 43-61

    6. Suicide Substrates: Mechanism-Based Inactivators of Specific Target Enzymes

      • C. Walsh
      Pages 62-77

    7. Recognition: the Kinetic Concepts

      • J. Ninio, F. Chapeville
      Pages 78-85

    8. Coupled Oscillator Theory of Enzyme Action

      • M. D. Williams, J. L. Fox
      Pages 86-96

    9. Stereochemical Aspects of Chain Lengthening and Cyclization Processes in Terpenoid Biosynthesis

      • O. Cori, L. Chayet, M. De La Fuente, L. A. Fernandez, U. Hashagen, L. Perez et al.
      Pages 97-110

  3. Enzyme Regulation

    1. Front Matter

      Pages 111-111
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    2. Three Multifunctional Protein Kinase Systems in Transmembrane Control

      • Y. Nishizuka
      Pages 113-135

    3. Effect of Catabolite Repression on Chemotaxis in Salmonella Typhimurium

      • D. E. Koshland Jr., M. J. Anderson
      Pages 136-143

    4. Subunit Interaction of Adenylylated Glutamine Synthetase

      • E. R. Stadtman, R. J. Hohman, J. N. Davis, M. Wittenberger, P. B. Chock, S. G. Rhee
      Pages 144-156

    5. Dynamic Compartmentation

      • B. Hess, A. Boiteux, E. M. Chance
      Pages 157-164

    6. The Genes for and Regulation of the Enzyme Activities of two Multifunctional Proteins Required for the De Novo Pathway for UMP Biosynthesis in Mammals

      • M. E. Jones
      Pages 165-182

    7. Regulation of Muscle Contraction by Ca Ion

      • S. Ebashi, Y. Nonomura, K. Kohama, T. Kitazawa, T. Mikawa
      Pages 183-194

    8. Why is Phosphate so Useful?

      • M. S. Bretscher
      Pages 195-196

    9. ppGpp, a Signal Molecule

      • J. Sy
      Pages 197-204

    10. Gramicidin S-Synthetase: On the Structure of a Polyenzyme Template in Polypeptide Synthesis

      • H. Kleinkauf, H. Koischwitz
      Pages 205-216
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Keywords

About this book

Studies of chemical recognition in biology were initiated about half a century ago with the flrst kinetic data obtained on enzyme catalysis and inhibition. They led to a rather static representation of the recognition process illustrated by the lock and key model that still continues to influence our overall image of recognition and its specificity. In several cases, crystallographic studies of enzyme-substrate complexes have supported this model. Indeed, in a crystallized ligand-enzyme complex, a close fltting is observed between the active center of the enzyme and the functional groups of the ligand. How­ ever, this does not necessarily result from a direct recognition process between rigid structures, but may result from a progressive adaptation during which the initial struc­ tures of the enzyme and the ligand are modified (induced-flt mechanism). Recently, a great deal of work has been devoted to the study of recognition in more complex systems such as the replication or the translation machin~ries; clearly, the extraordinary precision of such systems cannot be explained solely in terms of physical matching between enzymes and their substrates. This has led to a noticeable change of perspective in these areas. As a result of the new kinetic viewpoint, one rather focuses on the time-course of the processes, on the kinetic balance between steps of the reaction, on the energy-accuracy relationships and on the strategies which permit the achievement of high precision using relatively error-prone components in an appropriate dynamic interplay.

Editors and Affiliations

  • CNRS, Inst. de recherche en biologie moléculaire, Université Paris VII, Paris Cedex 05, France

    F. Chapeville, A.-L. Haenni

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