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Lymphocytes, Macrophages, and Cancer

  • Book
  • © 1976

Overview

Editors:
  1. Georges Mathé

    1. Institut de Cancérologie et d’Immunogénétique (INSERM), Hôpital Paul-Brousse, Villejuif, France

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  2. Irène Florentin

    1. Institut de Cancérologie et d’Immunogénétique (INSERM), Hôpital Paul-Brousse, Villejuif, France

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  3. Marie-Christine Simmler

    1. Institut de Cancérologie et d’Immunogénétique (INSERM), Hôpital Paul-Brousse, Villejuif, France

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Part of the book series: Recent Results in Cancer Research (RECENTCANCER, volume 56)

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Table of contents (18 chapters)

  1. Front Matter

    Pages I-IX
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  2. Morphological Recognition of Lymphocytes and Macrophages

    • D. Catovsky
    Pages 1-7

  3. Revised Semiology of the Different Mononuclear Cells Under Scanning Electron Microscopy

    • D. Dantchev
    Pages 8-16

  4. Immunologic Definition of Lymphocytes: Functions and Markers

    • G. Stathopoulos, A. J. S. Davies
    Pages 17-23

  5. In vitro Interactions Between Tumor Cells and Immune Lymphoid Cells

    • J. P. Levy, E. Gomard, A. Senik, J. C. Leclerc
    Pages 24-30

  6. Activation and Cytotoxic Activity of Macrophages: A Short Review

    • J. Mauel
    Pages 31-40

  7. Cell-Membrane Activation of Macrophage Function

    • P. C. Wilkinson
    Pages 41-48

  8. Lymphocyte-Macrophage Interactions in BCG-Treated Mice

    • I. Florentin, M. Bruley-Rosset, M. Davigny
    Pages 49-57

  9. Liposomes as Immunological Adjuvants

    • A. C. Allison, G. Gregoriadis
    Pages 58-64

  10. Nonspecific Immunodepression Induced by Tumor-Cell Extracts

    • R. Huchet, J. Lheritier
    Pages 65-71

  11. Increase in “Null” Cells in Acute Lymphocytic Leukemia in Remission on Long-Term Immunotherapy

    • R. R. Joseph, D. Belpomme
    Pages 72-78

  12. Participation of Leukemia Cells in Immune Responses

    • M. Boranič, M. Poljak-Blaži, M. Radačić, J. Gabrilovac, I. Hršak
    Pages 79-86

  13. Morphological Characterisation of Adult Acute Leukaemia in Short-Term Liquid Culture

    • F. R. Balkwill, R. T. D. Oliver
    Pages 87-90

  14. Surface Cell Markers in Human Lymphoid Malignancies

    • M. Seligmann, J. L. Preud’homme, J. C. Brouet
    Pages 91-97

  15. An Immunological Classification of Leukemias and Hematosarcomas Based on Cell Membrane Markers with Special Reference to Null Cell Disorders

    • D. Belpomme, N. Lelarge, F. Feuilhade de Chauvin, R. Joseph, G. Mathé
    Pages 98-110

  16. Hodgkin’s Disease: A War Between T-Lymphocytes and Transformed Macrophages?

    • M. M. B. Kay
    Pages 111-121

  17. The Significance of the Macrophage Content of Human Tumours

    • C. L. Gauci
    Pages 122-130

  18. Search for Correlations Between Immunological and Morphological Criteria Used to Classify Lymphoid Leukemias and Non-Hodgkin’s Hematosarcomas with Special Reference to Scanning Electron Microscopy and T and B Membrane Markers

    • D. Belpomme, D. Dantchev, A. M. Karima, N. Lelarge, R. Joseph, B. Caillou et al.
    Pages 131-143

  19. Non-Hodgkin’s Hematosarcoma (“Lymphomas”): Classification of the W. H. O. Reference Center for Neoplastic Disease of Hemopoietic and Lymphoid Tissues

    • G. Mathé, D. Dantchev
    Pages 144-160

  20. Back Matter

    Pages 161-162
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Keywords

About this book

Fresh living Bacillus Calmette-Guerin (BeG), injected i.v. into (C57BI/ 6xDBA/2)FI mice, activated peritoneal macrophages rendering them highly cytotoxic for tumor cells in vitro. This cytotoxic activity w~s already maximal 14 days after injection of 1 mg of BCG and remained stable when 3 or 5 mg of BCG were given. At the same time spleen cells of the BCG-treat~d mice showed strongly depressed responses to the T-cell mitogens,PHA and Con A, irrespective of the dose of BCG injected. The inhibitory effect was shown to be mediated by suppressor cells which had characteristics of macrophages since they could be removed by carbonyl iron and magnet treatment and were adherent to plastic. In contrast to it was observed after injec­ tion of 1 mg of BCG, these suppressor cells alone did not account for the depression of T-cell re.sponses induced by higher doses of BCG. Nylon-nonadherent cell populations obtained from spleen cells treated with 3 or 5 mg BCG partially retained the inhibitory activity suggesting that suppressor T cells were also induced after injection of high doses of BCG. In contrast, the responses to the B-cell mitogen LPS of unfractionated and macrophage-depleted spleen cells were not affected or significantly enhanced depending on the dose of BCG injected.

Editors and Affiliations

  • Institut de Cancérologie et d’Immunogénétique (INSERM), Hôpital Paul-Brousse, Villejuif, France

    Georges Mathé, Irène Florentin, Marie-Christine Simmler

Bibliographic Information

  • Book Title: Lymphocytes, Macrophages, and Cancer

  • Editors: Georges Mathé, Irène Florentin, Marie-Christine Simmler

  • Series Title: Recent Results in Cancer Research

  • DOI: https://doi.org/10.1007/978-3-642-81049-7

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin · Heidelberg 1976

  • Softcover ISBN: 978-3-642-81051-0Published: 13 December 2011

  • eBook ISBN: 978-3-642-81049-7Published: 06 December 2012

  • Series ISSN: 0080-0015

  • Series E-ISSN: 2197-6767

  • Edition Number: 1

  • Number of Pages: X, 162

  • Number of Illustrations: 34 b/w illustrations

  • Topics: Oncology

  • Industry Sectors: Biotechnology, Health & Hospitals, Pharma

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