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  • Conference proceedings
  • © 1996

Acute Leukemias V

Experimental Approaches and Management of Refractory Disease

Part of the book series: Haematology and Blood Transfusion Hämatologie und Bluttransfusion (HAEMATOLOGY, volume 37)

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Table of contents (105 papers)

  1. Front Matter

    Pages I-XXVI
  2. Leukemia Cell Biology

    1. Front Matter

      Pages 1-1
    2. CD34 and CD38 Expression on Blasts in Myelodysplastic Syndromes and Secondary AML

      • W. Verbeek, C. Ries, D. Grove, M. Unterhalt, W. Hiddemann, B. Wörmann
      Pages 11-14
    3. Heterogeneity of HRX-FEL Fusion Transcripts in Adult and Pediatric t(4;11) ALL

      • F. Griesinger, T. Jahn, H. Elfers, W.-D. Ludwig, M. Falk, H. Rieder et al.
      Pages 15-21
  3. Pharmacokinetics — Clinical Implications

    1. Front Matter

      Pages 23-23
    2. Fludarabine and Ara-C Combination for Treatment of Adult Acute Myelogenous Leukemia: Pharmacokinetic and Pharmacodynamic Effects

      • Varsha Gandhi, Min Du, Amy J. Chapman, Peng Huang, Elihu Estey, Michael J. Keating et al.
      Pages 25-31
    3. Pharmacokinetics of Ara-CMP-Stearate (YNK01) — Phase I Study of the Oral Ara-C Derivative

      • Jan Braess, Eberhard Schleyer, Bernhard Ramsauer, Michael Unterhalt, Cornelia Kaufmann, Sabine Wilde et al.
      Pages 32-40
    4. Differential Effect of GM-CSF on the Intracellular Ara-C Metabolism in Normal Bone Marrow Mononuclear Cells and Acute Myeloid Leukemia (AML) Blasts

      • Christoph Reuter, Claus Rolf, Eberhard Schleyer, Michael Unterhalt, Bernhard Woermann, Thomas Buechner et al.
      Pages 41-49
    5. Intracellular Retention of Cytosine-Arabinoside-Triphosphate in Leukemic Blast Cells from Children

      • J. Boos, M. Schiller, B. Pröbsting, U. Creutzig, J. Ritter
      Pages 50-53
    6. Targeted Drug Therapy in Childhood Acute Lymphoblastic Leukemia

      • Mary V. Relling, Ching-Hon Pui, William E. Evans
      Pages 62-66
    7. Asparagine Levels in Children on E. Coli- and Erwinia-Asparaginase Therapy

      • J. Boos, G. Werber, E. Verspohl, E. Ahlke, U. Nowak-Göttl, H. Jürgens
      Pages 67-69
  4. Chemo-Resistance

    1. Front Matter

      Pages 71-71
    2. Pharmacologic Modulation of Multidrug Resistance in Acute Leukemia: Results and Challenges

      • Alan F. List, Betty Glinsmann-Gibson, William S. Dalton
      Pages 73-78
    3. Expression of P-Glycoprotein in Children and Adults with Leukemia — Correlation with Clinical Outcome

      • Slawomir Kaczorowski, Maria Ochocka, Robert Aleksandrowicz, Maria Kaczorowska, Michal Matysiak, Marek Karwacki
      Pages 101-107
    4. Multidrug Resistance in Acute Myelogenous Leukemia: Relevance to Clinical and Laboratory Data

      • Andrey Zaritskey, Irina Stuf, Tatyana Bykova, Kirill Titov, Nadezhda Medvedeva, Natalya Anikina et al.
      Pages 108-111

About this book

This volume, the fifth in a series on acute leukemias, focuses particularly on recent basic research results and novel therapeutic approaches to the disease. Aspects of leukemia cell biology, including differentiation, the mechanisms of drug resistance, the pharmacology of cytostatic agents and the results of clinical trials in relapsed and refractory disease are covered by outstanding international experts in the respective fields. Future developments including new agents and new treatment options such as unrelated bone marrow transplantation, immunotargeting and gene therapy complete a state-of-the-art summery of current knowledge in experimental leukemia therapy.

Keywords

  • blood
  • bone marrow
  • cell
  • chemotherapy
  • cytogenetics
  • gene therapy
  • hematopoietic stem cell
  • hematopoietic stem cell transplantation
  • immunotherapy
  • leukemia
  • lymphocytes
  • lymphoma
  • stem cell
  • stem cell transplantation
  • transplantation

Editors and Affiliations

  • Department of Internal Medicine, University of Göttingen, Göttingen, Germany

    W. Hiddemann, W. Plunkett

  • Department of Internal Medicine, University of Münster, Münster, Germany

    T. Büchner

  • Department of Pediatric Oncology, University of Münster, Münster, Germany

    J. Ritter

  • Department of Internal Medicine, MD Anderson Cancer Center, Houston, USA

    B. Wörmann, M. J. Keating

  • Koordinierungsstelle, Deutsche Krebsgesellschaft e.V., Hannover, Germany

    U. Creutzig

Bibliographic Information

  • Book Title: Acute Leukemias V

  • Book Subtitle: Experimental Approaches and Management of Refractory Disease

  • Editors: W. Hiddemann, W. Plunkett, T. Büchner, J. Ritter, B. Wörmann, M. J. Keating, U. Creutzig

  • Series Title: Haematology and Blood Transfusion Hämatologie und Bluttransfusion

  • DOI: https://doi.org/10.1007/978-3-642-78907-6

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 1996

  • Softcover ISBN: 978-3-642-78909-0

  • eBook ISBN: 978-3-642-78907-6

  • Series ISSN: 0440-0607

  • Edition Number: 1

  • Number of Pages: XXVI, 613

  • Number of Illustrations: 54 b/w illustrations

  • Topics: Hematology, Oncology

  • Industry Sectors: Biotechnology, Health & Hospitals, Pharma

Buying options

eBook USD 84.99
Price excludes VAT (USA)
  • ISBN: 978-3-642-78907-6
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout
Softcover Book USD 109.00
Price excludes VAT (USA)