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Pharmacokinetics of Drugs

  • Peter G. Welling
  • Luc P. Balant

Part of the Handbook of Experimental Pharmacology book series (HEP, volume 110)

Table of contents

  1. Front Matter
    Pages I-XXVI
  2. Introduction

    1. Front Matter
      Pages 1-1
  3. Analytical Methods

    1. Front Matter
      Pages 21-21
    2. B. L. Ferraiolo, M. A. Mohler
      Pages 85-98
  4. In Vitro Methods-Protein and Tissue Binding

    1. Front Matter
      Pages 99-99
    2. J. P. F. Bai, B. H. Stewart, G. L. Amidon
      Pages 189-206
  5. Classical Problems

  6. Future Trends in Pharmacokinetics

    1. Front Matter
      Pages 353-353
    2. B. L. Ferraiolo, R. J. Wills, M. A. Mohler
      Pages 355-370
    3. C. McMartin
      Pages 371-382
    4. J. Kantrowitz, A. Yacobi
      Pages 383-403
    5. J.-L. Steimer, S. Vozeh, A. Racine-Poon, N. Holford, R. O’Neill
      Pages 405-451
  7. Impact of New Methods on Pharmacokinetics

    1. Front Matter
      Pages 453-453
    2. A. J. Fischman, R. H. Rubin, H. W. Strauss
      Pages 481-503
  8. Appendix

  9. Back Matter
    Pages 529-537

About this book

Introduction

The author of this Foreword has recently retired after spending 25 years in academia and 15 years in the pharmaceutical industry. Most of this time has been spent following and, hopefully in some instances, contributing to advancement of the discipline of pharmacokinetics. During the last 40 years, pharmacokinetics has grown from a fledgling in the 1950s to an adult in the 1990s. The late development of the discipline of pharmacokinetics, relative to other disciplines such as chemistry, bio­ chemistry, and pharmacology, probably stems both from general ignorance of the importance of the time course of concentration-effect relationships in drug therapy and from our technical inability to do anything about it had we been more enlightened. Just as the end of the historical dark ages had to await the beginning of the Carolingian revival, so the end of the pharma­ co kinetic dark age had to await the discovery of adequate analytical methods and also an intellectual leap of faith to accept that drug action is in some way dependent on receptor site occupancy, and therefore on drug con­ centration. The recent evolution of pharmacokinetics has occurred in three phases which may be identified as those of discovery, stabilization, and rationaliz­ ation. The discovery phase, which occurred in the 1950s and 1960s, esta­ blished the mathematics and concepts of "modern" pharmacokinetics and sought areas of application, ranging from model-independent methods, through compartment approaches, to complex physiological models.

Keywords

Bioanalytical Analysis Biotechnologie Biotechnology Computer Methods Drug Development Drug Metabolism Drugs Pharmacokinetics Pharmakologie Stereospecificity Stoffwechsel Transport Xenobiotics positron emission tomography

Editors and affiliations

  • Peter G. Welling
    • 1
  • Luc P. Balant
    • 2
  1. 1.Pharmacokinetics/Drug Metabolism Parke-Davis Pharmaceutical Research DivisionWarner-Lambert CompanyAnn ArborUSA
  2. 2.Clinical Research UnitDepartment of PsychiatryGenevaSwitzerland

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-78680-8
  • Copyright Information Springer-Verlag Berlin Heidelberg 1994
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-78682-2
  • Online ISBN 978-3-642-78680-8
  • Series Print ISSN 0171-2004
  • Series Online ISSN 1865-0325
  • Buy this book on publisher's site
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