Nucleic Acids and Molecular Biology

1. Front Matter

   Pages I-XI

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2. Probing of DNA Structure with Osmium Tetroxide Complexes in Vitro and in Cells

   • E. Paleček

   Pages 1-13

3. The Convertible Nucleoside Approach: Structural Engineering of Nucleic Acids by Disulfide Cross-Linking

   • A. E. Ferentz, G. L. Verdine

   Pages 14-40

4. Cryo-Electron Microscopy of DNA

   • J. Dubochet, J. Bednar, P. Furrer, A. Stasiak

   Pages 41-55

5. The Hairpin Elements of Nucleic Acid Structure: DNA and RNA Folding

   • C. W. Hilbers, H. A. Heus, M. J. P. van Dongen, S. S. Wijmenga

   Pages 56-104

6. The Hairpin Ribozyme

   • J. M. Burke

   Pages 105-118

7. Conformation and Energetics of Supercoiled DNA: Experimental and Theoretical Studies

   • S. D. Levene

   Pages 119-132

8. Supercoiling Induced by Transcription

   • D. N. Cook, D. Ma, J. E. Hearst

   Pages 133-146

9. Topological Coupling between Promoters

   • D. Chen, R. P. Bowater, D. M. J. Lilley

   Pages 147-166

10. Bleomycin-DNA Interactions

    • K. R. Fox, K. P. Nightingale

    Pages 167-183

11. Adaptability and Specificity in DNA Binding by trp Repressor

    • T. A. Lavoie, J. Carey

    Pages 184-196

12. The β Sliding Clamp of E. coli DNA Polymerase III Holoenzyme Balances Opposing Functions

    • M. O’donnell, J. Kuriyan, X.-P. Kong, P. T. Stukenberg, R. Onrust, N. Yao

    Pages 197-216

13. Structure and Function of T4 Endonuclease V

    • S. Iwai, E. Ohtsuka

    Pages 217-226

14. Structure and Function of the DNA Repair Enzyme Endonuclease III

    • R. P. Cunningham, M. M. Thayer, J. A. Tainer

    Pages 227-235

15. Resolvase-Mediated Site-Specific Recombination

    • N. D. F. Grindley

    Pages 236-267

16. Mechanism of Site-Specific Recombination: The Flp Paradigm

    • M. Jayaram

    Pages 268-286

17. Achilles’ Cleavage: Conferring the Specificities of DNA-Binding Molecules on Restriction Endonucleases

    • M. Koob, W. Szybalski

    Pages 287-297

18. Oligonucleotide-Based Therapeutics of Human Malignancies

    • M. Z. Ratajczak, A. M. Gewirtz

    Pages 298-326

19. Back Matter

    Pages 327-331

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Molecular biology is one of the most rapidly developing and at the same time most exciting disciplines. The key to molecular biology lies in the understanding of nucleic acids - their structure, function, and interaction with proteins.
Nucleic Acids and Molecular Biology keeps scientists informed of the explosively growing information and complies with the great interest in this field by offering a continued high standard of review. A substantial part of this volume has been devoted to the analysis of different aspects of nucleic acid-protein-interactions including RNA-protein-interaction.

• DNA
• DNA structure
• RNA
• RNA folding
• biology
• endonucleases
• molecular biology
• nucleic acid
• polymerase
• protein
• proteins
• ribozyme

• Max-Planck-Institut für Experimentelle Medizin, Göttingen, Germany

  Fritz Eckstein

• Biochemistry Department, University of Dundee, Dundee, UK

  David M. J. Lilley

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