The studies described here were carried out in the Neuroregul ation Group, Department of Physiology, University of Leiden, the Netherlands. Over the last decade, this group, in close collaboration with the Department of Neurosurgery of the Academic Hospital of Leiden, has studied the development of the central nervous system from a neuroanatomical as well as a clinical perspective. During this period, the expression of several morphore gulators in the developing rat spinal cord was extensively investigated. Parallel studies focused on the development of the spinal cord fiber systems, which was studied by means of the intrauterine use of neuronal tracers. The main goal of these studies was to extend our knowledge about the (normal) generation of the spinal cord and to contribute to the under standing of clinical problems related to regeneration and degeneration in the mammalian central nervous system. The studies on morphoregulators, in particular, appeared to benefit two different scientific areas. Firstly, the correlation between morphoregulator expression patterns and known anatomy contributed to our knowledge about spinal cord development. Secondly, the correlation between morpho regulator expression patterns and known developmental processes may help to understand their precise function(s). This volume of Advances in Anatomy, Embryology and Cell Biology presents these particular studies on the development of the rat spinal cord performed over the last decade. As well as integrating the results of the tracer studies, this volume also provides an update on the development of the rat spinal cord.
Authors and Affiliations
The Miami Project to Cure Paralysis, University of Miami, School of Medicine, Miami, USA
Martin Oudega
Neuroregulation Group, Department of Physiology, Leiden University, Leiden, The Netherlands
Egbert A. J. F. Lakke,
Enrico Marani
Neuroregulation Group, Department of Neurosurgery, Leiden Academic Hospital, Leiden, The Netherlands
Raph. T. W. M. Thomeer
Bibliographic Information
Book Title: Development of the Rat Spinal Cord: Immuno- and Enzyme Histochemical Approaches
Authors: Martin Oudega, Egbert A. J. F. Lakke, Enrico Marani, Raph. T. W. M. Thomeer
Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag GmbH, DE, part of Springer Nature 1993
Softcover ISBN: 978-3-540-57173-5Published: 20 December 1993
eBook ISBN: 978-3-642-78474-3Published: 06 December 2012
