Neurological Adverse Reactions to Anticancer Drugs

1. Front Matter

   Pages I-VII

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2. Purposes and Plan

   • Jerzy Hildebrand

   Pages 1-1

3. The Blood-Brain Barrier: Morphology, Physiology and its Changes in Cancer Patients

   • Jean-Yves Delattre, Jerome B. Posner

   Pages 3-24

4. Mechanisms of Neurotoxicity and Experimental Models

   • Diamon Gangji, Jerzy Hildebrand, Roland Gerritsen van der Hoop

   Pages 25-43

5. Neurotoxicity of Combined Radiation and Chemotherapy

   • Roland Gerritsen van der Hoop, Lisa M. DeAngelis, Jerome B. Posner

   Pages 45-53

6. Acute Encephalopathy and Seizures

   • Jerome B. Posner

   Pages 55-65

7. Chronic Encephalopathies

   • Francesc Graus

   Pages 67-73

8. Cerebellar Disorders

   • Jerome B. Posner

   Pages 75-81

9. Acute Meningeal Reaction

   • Jerzy Hildebrand

   Pages 83-85

10. Acute Meningospinal Syndromes: Acute Myelopathy and Radiculopathy

    • Francesc Graus

    Pages 87-92

11. Peripheral Neuropathy

    • Jerzy Hildebrand

    Pages 93-99

In this timely and up-to-date book, the latest knowledge on neurological syndromes due to neurotoxicity of antineoplastic drugs is presented. The initial chapters discuss the following vital topics: - the importance of blood-brain barrier changes in cancer patients, - laboratory and clinical studies on the neurotoxicity of anticancer drugs, - and the role of cumulative toxicity of radiation therapy and chemotherapy. Clinical presentation and diagnosis of various neurological conditions related to antineoplastic chemotherapy are then also thoroughly discussed. Indispensable to the neuro-oncologist and useful to all physicians managing cancer patients, this book is a valuable source of current information.

• Antineoplastic drugs
• cancer
• chemotherapy
• nervous system
• neurotoxicity
• oncology
• physiology
• radiation therapy
• toxicity

• Service de Neurologie, Hôpital Erasme Université Libre de Bruxelles, Bruxelles, Belgium

  Jerzy Hildebrand

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