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The Pathology of the Endocrine Pancreas in Diabetes

  • Book
  • © 1988

Overview

Editors:
  1. Pierre J. Lefèbvre

    1. Division of Diabetes, Nutrition and Metabolic Disorders Department of Medicine, Centre Hospitalier Universitaire du Sart-Tilman, Liège 1, Belgium

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  2. Daniel G. Pipeleers

    1. Dept. of Metabolism and Endocrinology, Vrije Universiteit Brussel, Brussels, Belgium

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    You can also search for this editor in PubMed   Google Scholar

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Table of contents (17 chapters)

  1. Front Matter

    Pages I-XI
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  2. Clinical Forms of Diabetes Mellitus

    • P. J. Lefèbvre
    Pages 1-16

  3. The Diabetic Pancreas: A Pathologist’s View

    • J. Rahier
    Pages 17-40

  4. Insulitis in the Human Pancreas

    • A. K. Foulis, G. F. Bottazzo
    Pages 41-52

  5. Circulating Signs of Autoimmune Islet Disease

    • Ä. Lernmark, H. Markholst, S. Baekkeskov
    Pages 53-70

  6. Immune Interactions with Islet Cells: Implications for the Pathogenesis of Insulin-Dependent Diabetes Mellitus

    • J. Nerup, T. Mandrup-PouIsen, J. Mølvig, G. Spinas
    Pages 71-84

  7. Viral Interactions with Pancreatic B-Cells

    • E. H. Leiter, G. L. Wilson
    Pages 85-105

  8. Death of the Pancreatic B-Cell

    • D. G. Pipeleers, P. A. In’t Veld, M. Van De Winkel
    Pages 106-124

  9. Disturbed Growth of the Endocrine Pancreas

    • S. Falkmer, U. Askensten
    Pages 125-140

  10. Islet Cell Replication and Diabetes

    • C. Hellerström, I. Swenne, A. Andersson
    Pages 141-170

  11. Islet Cell Tumors and Diabetes Mellitus

    • G. Somers, M. De Vroede
    Pages 171-190

  12. Insulin Secretion in Diabetes Mellitus

    • E. Cerasi
    Pages 191-218

  13. Possible Sites for Deficient Glucose Recognition in Islet Cells

    • W. J. Malaisse
    Pages 219-232

  14. Insulin Release and Islet Cell Junctions

    • P. A. In’t Veld
    Pages 233-248

  15. Calcium Transport and Deficient Insulin Release

    • B. Hellman
    Pages 249-268

  16. Autoimmune Diabetes in the BioBreeding/Worcester Rat

    • A. A. Like, E. J. Weringer
    Pages 269-284

  17. Rat Models of Non-Insulin-Dependent Diabetes Mellitus: Evidence that Mild Increases in Plasma Glucose Play an Important Role in Pathogenesis

    • J. L. Leahy, S. Bonner-Weir, G. C. Weir
    Pages 285-309

  18. Perspectives of Islet Cell Transplantation in Diabetes

    • P. E. Lacy
    Pages 310-328

  19. Back Matter

    Pages 329-336
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Keywords

About this book

Diabetes mellitus represents one of the most frequent and serious clinical syn­ dromes in contemporary medicine. Since the end of the nineteenth century, the endocrine pancreas has been implicated in the pathogenesis of this disease. Several pathologists of the twentieth century detected various lesions and mor­ phologic alterations in the pancreatic islets of diabetic patients, but the patho­ physiologic basis of their findings remained long obscure. The systematic mi­ croscopic work of WILLY GEPTS clarified the views and related the variety in histopathology to differences in origin, duration and clinical expression of the disease. Over the past two decades, the concept of a multifactorial origin of diabetes has become widely accepted. Various agents and mechanisms have been identified which can lead to a quantitative or qualitative deficit in pancre­ atic B-cells. The purpose of this book is to bring an update on the many path­ ways which may induce an absolute or relative insufficiency in insulin release and hence a diabetic state. Rather than bringing a complete account on all re­ search relevant to the understanding of the pathology of the diabetic pancreas, the authors of the various chapters of this volume have focussed on selected processes which can impair B-cell function, survival or regeneration.

Editors and Affiliations

  • Division of Diabetes, Nutrition and Metabolic Disorders Department of Medicine, Centre Hospitalier Universitaire du Sart-Tilman, Liège 1, Belgium

    Pierre J. Lefèbvre

  • Dept. of Metabolism and Endocrinology, Vrije Universiteit Brussel, Brussels, Belgium

    Daniel G. Pipeleers

Bibliographic Information

  • Book Title: The Pathology of the Endocrine Pancreas in Diabetes

  • Editors: Pierre J. Lefèbvre, Daniel G. Pipeleers

  • DOI: https://doi.org/10.1007/978-3-642-72691-0

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 1988

  • Softcover ISBN: 978-3-642-72693-4Published: 21 December 2011

  • eBook ISBN: 978-3-642-72691-0Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: XI, 336

  • Topics: Metabolic Diseases, Endocrinology, Allergology, Immunology

  • Industry Sectors: Biotechnology, Health & Hospitals, Pharma

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