Advertisement

The Sodium Pump

Structure Mechanism, Hormonal Control and its Role in Disease

  • Ernst Bamberg
  • Wilhelm Schoner

Table of contents

  1. Front Matter
    Pages I-XIX
  2. Gene organization, analysis of the sodium pump by molecular biology

    1. K. Kawakami, Y. Suzuki-Yagawa, Y. Watanabe, K. Ikeda, K. Nagano
      Pages 1-10
    2. Robert A. Farley, Kurt A. Eakle, Georgios Scheiner-Bobis, Kena Wang
      Pages 11-20
    3. R. W. Mercer, G. Blanco, A. W. De Tomaso, J. C. Koster, Z. J. Xie
      Pages 21-32
    4. Trine Kjærsig, Peter L. Jørgensen, Li-Mei Meng
      Pages 37-40
    5. Z. J. Xie, H. Li, Q. Liu, Y. Wang, A. Askari, R. W. Mercer
      Pages 49-52
    6. Karl Lücking, Peter L. Jørgensen, Li-Mei Meng
      Pages 53-56
    7. C. P. Cutler, I. L. Sanders, G. A. Luke, N. Hazon, G. Cramb
      Pages 57-60
    8. P. M. Mathews, D. Claeys, F. Jaisser, K. Geering, J.-P. Kraehenbuhl, B. C. Rossier
      Pages 61-65
    9. Per Amstrup Pedersen, Vibeke Foersom, Peter Leth Jørgensen
      Pages 70-73
    10. K. K. Grindstaff, G. Blanco, R. W. Mercer
      Pages 74-77
    11. G. Blanco, A. W. De Tomaso, J. C. Koster, Z. J. Xie, R. W. Mercer
      Pages 78-81
    12. G. Blanco, Z. J. Xie, R. W. Mercer
      Pages 82-85
    13. J. C. Koster, M. A. Reuben, G. Sachs, R. W. Mercer
      Pages 90-93
    14. C. H. W. Klaassen, M. P. De Moel, H. G. P. Swarts, J. J. H. H. M. De Pont
      Pages 94-97

About this book

Introduction

The sodium of animal cell membranes converts the chemical energy obtained from the hydrolysis of adenosine 5' -triphosphate into a movement of the cations Na + and K + against an electrochemical gradient. The gradient is used subse­ quently as an energy source to drive the uptake of metabolic substrates in polar epithelial cells and to use it for purposes of communications in excitable cells. The biological importance of the sodium pump is evident from the fact that be­ tween 20-70% of the cell's metabolic energy is consumed for the pumping pro­ cess. Moreover, the sodium pump is an important biological system involved in regulatory processes like the maintenance of the cells' and organism's water me­ tabolism. It is therefore understandable that special cellular demands are han­ dled better by special isoforms of the sodium pump, that the expression of the sodium pump and their isoforms is regulated by hormones as is the activity of the sodium pump via hormone-regulated protein kinases. Additionally, the sodium pump itself seems to be a receptor for a putative new group of hormones, the endogenous digitalis-like substances, which still have to be defined in most cases in their structure. This group of substances has its chemically well known coun­ terpart in steroids from plant and toad origin which are generally known as "car­ diac glycosides". They are in medical use since at least 200 years in medicine in the treatment of heart diseases.

Keywords

Alanin Calcium Nucleotide amino acid biology cell biology cell membrane cells enzyme enzymes gene expression kidney membrane transport pharmacology proteins

Editors and affiliations

  • Ernst Bamberg
    • 1
  • Wilhelm Schoner
    • 2
  1. 1.Max-Planck-Institut für BiophysikFrankfurtGermany
  2. 2.Institut für BiochemieUniversität GießenGießenGermany

Bibliographic information

Industry Sectors
Biotechnology
Consumer Packaged Goods
Pharma