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Pharmacology of Intestinal Permeation I

  • Tihamér Z. Csáky

Part of the Handbook of Experimental Pharmacology book series (HEP, volume 70 / 1)

Table of contents

  1. Front Matter
    Pages I-XX
  2. K. E. Carr, P. G. Toner
    Pages 1-50
  3. W. D. Stein
    Pages 195-252
  4. D. S. Parsons
    Pages 253-282
  5. W. McD. Armstrong, J. F. Garcia-Diaz
    Pages 309-380
  6. K. Turnheim
    Pages 381-463
  7. H. Huebers, W. Rummel
    Pages 513-541
  8. E. C. Foulkes
    Pages 543-565
  9. Back Matter
    Pages 691-710

About this book

Introduction

The intestine, particularly the small bowel, represents a large surface (in the adult 2 human approximately 200m ) through which the body is exposed to its environment. A vigorous substrate exchange takes place across this large surface: nutrients and xenobiotics are absorbed from the lumen into the bloodstream or the lymph, and simultaneously, the same types of substrate pass back into the lumen. The luminal surface of the intestine is lined with a "leaky" epithelium, thus the passage of the substrates, in either direction, proceeds via both transcellular and intercellular routes. Simple and carrier-mediated diffusion, active transport, pinocytosis, phagocytosis and persorption are all involved in this passage across the intestinal wall. The term "intestinal permeation" refers to the process of passage of various substances across the gut wall, either from the lumen into the blood or lymph, or in the opposite direction. "Permeability" is the condition of the gut which governs the rate of this complex two-way passage. The pharmacologist's interest in the problem of intestinal permeation is twofold: on the one hand, this process determines thebioavailability of drugs and contributes significantly to the pharmacokinetics and toxicokinetics of xeno­ biotics; on the other hand, the pharmacodynamic effects of many drugs are manifested in a significant alteration of the physiological process of intestinal permeation.

Keywords

Permeation kinetics pharmacokinetics pharmacology research

Editors and affiliations

  • Tihamér Z. Csáky
    • 1
  1. 1.Department of PharmacologyUniversity of Missouri-Columbia School of MedicineColumbiaUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-69505-6
  • Copyright Information Springer-Verlag Berlin Heidelberg 1984
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-69507-0
  • Online ISBN 978-3-642-69505-6
  • Series Print ISSN 0171-2004
  • Series Online ISSN 1865-0325
  • Buy this book on publisher's site
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