Immunodermatology

1. Front Matter

   Pages I-VI

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2. Introduction

   • Peter A. Miescher

   Pages 1-1

3. Immunologically Mediated Epidermal Cell Injury

   • Richard D. Sontheimer, James N. Gilliam

   Pages 3-17

4. Antibody-Induced Proteinase Activation: A Proposed Mechanism for Pemphigus

   • Kay Hiemstra Singer, Koji Hashimoto, Gerald S. Lazarus

   Pages 19-34

5. Dermatitis Herpetiformis

   • Russell P. Hall, Thomas J. Lawley, Stephen I. Katz

   Pages 35-45

6. Erythema Multiforme: Clinical Spectrum and Immunopathogenesis

   • John A. Kazmierowski, Kirk D. Wuepper

   Pages 47-55

7. Biology of the Mast Cell and Its Role in Cutaneous Inflammation

   • Bruce U. Wintroub, Nicholas A. Soter

   Pages 57-65

8. Mast Cell-Dependent Effector Pathways and Cutaneous Bullous Disorders

   • Bruce U. Wintroub, Martin C. Mihm

   Pages 67-74

9. Physical Urticaria/Angioedema as an Experimental Model of Acute and Chronic Inflammation in Human Skin

   • Nicholas A. Soter

   Pages 75-83

10. The Role of Complement in Phototoxic Reactions

    • Henry Lim, Irma Gigli

    Pages 85-95

11. Circulating Immune Complexes in Dermatologic Disease

    • Thomas J. Lawley, Russell P. Hall

    Pages 97-116

12. Infections in Patients with Abnormal Granulocyte Chemotaxis

    • Paul G. Quie

    Pages 117-128

13. Ro (SSA) and La (SSB) Antibodies

    • Elaine L. Alexander, Thomas T. Provost

    Pages 129-149

14. Immune Mechanisms in Atopic Dermatitis

    • Donald Y. M. Leung, Raif S. Geha

    Pages 151-167

15. Suppression of Contact Hypersensitivity by Ultraviolet Radiation: An Experimental Model

    • Frances P. Noonan, Edward C. De Fabo, Margaret L. Kripke

    Pages 169-180

16. Conclusions

    • Irma Gigli

    Pages 181-183

17. Back Matter

    Pages 185-186

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Peter A. Miescher The skin has always been one of the major targets to clinicians interested in immunology. Initially, the main focus was centred on allergic conditions such as contact hypersensitivity and urticeria. Gradually, the spectrum of immunological conditions involving the skin increased, encompassing diseases such as Dermatitis Herpetiformis, Erythema Muitiforme, Cutaneous Bullous Disorders and Photo­ toxic Reactions. It has been the intention of the editors of Springer Seminars in Immu­ nopathology to cover the broad spectrum of immune phenomena encountered in dermatological diseases with special emphasis to newer developments in Immunopathology. Dr. 1. N. Gigli has managed to assemble a series of important contributions within two issues of the Journal which are of such an interest to dermatologists that we decided to publish this topic as a separate volume for all dermatologists who do not have access to Seminars in Immunopathology. 3 Immunologically Mediated Epidermal Cell Injury Richard D. Sontheimer* and James N. Gilliam Division of Dermatology, University of Texas Health Science Center, 5323 Harry Hines Boulevard, Dallas, Texas 75235, USA Introduction The epidermis is a functional unit of different cell types that has the critical role of protecting man from his environment. The three major cell types that make up the epidermis (keratinocytes, melanocytes, and Langerhans cells) serve different protective functions. The vast majority of epidermal cells are keratinocytes (Fig. 1).

• Dermatitis
• Hautkrankheit
• Immunopathologie
• Urticaria
• diseases
• infection
• infections
• inflammation
• pathogenesis
• pathology
• skin disease

• Department of Dermatology, University of California, San Diego, University Hospital, San Diego, USA

  Irma N. Gigli

• Division d’Hématologie du Department de Médicine, Hôpital Cantonal, Genève, Switzerland

  Peter A. Miescher

• Department of Molecular Immunology, Scripps Clinic and Research Foundation, La Jolla, USA

  Hans J. Müller-Eberhard

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