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Chemotherapy of Viral Infections

  • Paul E. Came
  • Lawrence A. Caliguiri

Part of the Handbook of Experimental Pharmacology book series (HEP, volume 61)

Table of contents

  1. Front Matter
    Pages I-XXV
  2. Pathogenesis of Viral Infections

    1. J. Hay, M. J. Bartkoski Jr.
      Pages 1-91
  3. Part A

    1. Front Matter
      Pages 93-93
    2. P. H. Fischer, W. H. Prusoff
      Pages 95-116
    3. N. H. Park, D. Pavan-Langston
      Pages 117-136
    4. J. L. Schulman
      Pages 137-146
    5. C. J. Pfau
      Pages 147-204
    6. P. B. Sehgal, L. M. Pfeffer, I. Tamm
      Pages 205-311
    7. H. Friedman, S. Specter
      Pages 313-339
  4. Part B

    1. Front Matter
      Pages 341-341
    2. D. R. Tershak, F. H. Yin, B. D. Korant
      Pages 343-375
    3. H. J. Eggers
      Pages 377-417
    4. J. J. McSharry, F. Pancic
      Pages 419-444
    5. L. R. Overby
      Pages 445-477
    6. P. E. Came, B. A. Steinberg
      Pages 479-518
    7. C. Gurgo, S. Bridges, M. Green
      Pages 519-555
  5. Back Matter
    Pages 557-566

About this book

Introduction

" . . . the motto for the therapeutics of the future will have to be de sedibus et causis pharmacorum. " P. EHRLICH, 1909 Exciting events in the basic disciplines of virology, immunology, and pharmacology continue to advance the understanding of the pathogenesis and control of virus diseases. At the same time, the rational development of antiviral agents is attracting, to an increasing extent, the interest of workers in other disciplines. Improvements in technology facilitate the definition of potential target sites for antiviral intervention and unmask new viral and host genes. The outcome is a further steady development of new antiviral agents which approach the "magic bullets" first proposed by PAUL EHRLICH. Remarkable advances in protein synthetic methods that yield polypeptides which inhibit active sites of viral proteins have aided substantially in the basic and clinical study of these antiviral agents. In addition, the extremely rapid progression in recombinant DNA techniques, leading to the synthesis of large quantities of gene products, is also increasing our opportunities at a dashing pace. New information and developing technology facilitate research on the mechanism of action, toxicity, pharmacokinetics, and pharmacodynamics of new agents. The list of clinically effective antiviral agents is expanding and the number of potentially useful compounds is growing rapidly. This book is a combined theoretical text and practical manual which, it is hoped, will be of use to all who have an interest in virus diseases, particularly scientists, physicians and graduate students.

Keywords

Arzneitherapie Infections Viruskrankheit chemotherapy immunology kinetics pharmacodynamics pharmacokinetics pharmacology research toxicity

Editors and affiliations

  • Paul E. Came
    • 1
  • Lawrence A. Caliguiri
    • 2
  1. 1.Sterling-Winthrop Research InstituteRensselaerUSA
  2. 2.Department of MicrobiologyUniversity of Pittsburgh, School of MedicinePittsburghUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-68487-6
  • Copyright Information Springer-Verlag Berlin Heidelberg 1982
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-68489-0
  • Online ISBN 978-3-642-68487-6
  • Series Print ISSN 0171-2004
  • Series Online ISSN 1865-0325
  • Buy this book on publisher's site
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