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Mediators and Drugs in Gastrointestinal Motility II

Endogenous and Exogenous Agents

  • Book
  • © 1982

Overview

Editors:
  1. Giulio Bertaccini

    1. School of Medicine, University of Parma, Parma, Italy

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Part of the book series: Handbook of Experimental Pharmacology (HEP, volume 59 / 2)

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Table of contents (11 chapters)

  1. Front Matter

    Pages I-XVIII
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  2. Endogenous Substances Which Can Affect Gastrointestinal Motility

    • G. Bertaccini
    Pages 1-10

  3. Peptides: Gastrointestinal Hormones

    • G. Bertaccini
    Pages 11-83

  4. Peptides: Candidate Hormones

    • G. Bertaccini
    Pages 85-135

  5. Peptides: Pancreatic Hormones

    • G. Bertaccini
    Pages 137-159

  6. Peptides: Other Hormones

    • G. Bertaccini
    Pages 161-174

  7. Peptides: Locally Active Peptides (“Vasoactive Peptides”)

    • G. Bertaccini
    Pages 175-200

  8. Amines: Histamine

    • G. Bertaccini
    Pages 201-218

  9. Acidic Lipids: Prostaglandins

    • A. Bennett, G. J. Sanger
    Pages 219-248

  10. Pharmacology of Adrenergic, Cholinergic, and Drugs Acting on Other Receptors in Gastrointestinal Muscle

    • E. E. Daniel
    Pages 249-322

  11. Hydrophilic Colloids in Colonic Motility

    • M. A. Eastwood, A. N. Smith
    Pages 323-346

  12. Motility and Pressure Studies in Clinical Practice

    • A. Torsoli, E. Corazziari
    Pages 347-376

  13. Back Matter

    Pages 377-388
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Keywords

About this book

This volume places more emphasis on endogenous mediators of gut motility than on drugs used to treat patients with deranged motility. In this respect it resembles most other books on gastroenterology, for while only a relatively small number of drugs are really useful for a rational therapy, a tremendous amount of data is available on neural and hormonal factors regulating the motility of the alimentary canal. Moreover, it must be considered that some of the drugs which can routinely be employed to modify deranged motility of the digestive system are represented by pure or slightly modified endogenous compounds (e. g. , cholecystokinin, its C­ terminal octapeptide and caerulein), and it is easy to foresee that their number is destined to increase in the near future. Other drugs are simply antagonists of physiological substances acting on specific receptors (e. g. , histamine H -blockers 2 and opioid compounds). The real explosion of research in this field and the extreme specialization often connected with the use of very sophisticated techniques and methodologies would probably have required a larger number of experts to cover some very specific fields from both an anatomical (lower esophageal sphincter, stomach, pylorus, small and large intestine) and a biochemical (hormones, candidate hormones, locally active substances, neurotransmitters etc. ) point of view.

Editors and Affiliations

  • School of Medicine, University of Parma, Parma, Italy

    Giulio Bertaccini

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