Cyclic Nucleotides

1. Front Matter

   Pages I-XX

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2. Biochemistry of Cyclic Nucleotides

   1. Front Matter

      Pages 1-1

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   2. Formation and Degradation of Cyclic Nucleotides: An Overview

      • T. W. Rall

      Pages 3-16

   3. Chemistry of Cyclic Nucleotides and Cyclic Nucleotide Analogs

      • G. R. Revankar, R. K. Robins

      Pages 17-151

   4. Coupling of Receptors to Adenylate Cyclases

      • L. Birnbaumer, R. Iyengar

      Pages 153-183

   5. Acute and Chronic Modulation of the Responsiveness of Receptor-Associated Adenylate Cyclases

      • J. P. Perkins, T. K. Harden, J. F. Harper

      Pages 185-224

   6. Guanylate Cyclase: Regulation of Cyclic GMP Metabolism

      • C. K. Mittal, F. Murad

      Pages 225-260

   7. Cyclic Nucleotide Phosphodiesterases

      • M. M. Appleman, M. A. Ariano, D. J. Takemoto, R. H. Whitson

      Pages 261-300

   8. Calmodulin Regulation of Cyclic AMP Metabolism

      • W. Y. Cheung, D. R. Storm

      Pages 301-323

   9. Radioimmunoassay Techniques for Cyclic Nucleotides

      • G. Brooker

      Pages 325-332

   10. Immunocytochemistry of Cyclic Nucleotides and Their Kinases

       • C. L. Kapoor, A. L. Steiner

       Pages 333-354

3. Biochemistry of Protein Phosphorylation

   1. Front Matter

      Pages 355-355

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   2. Protein Phosphorylation: An Overview

      • P. Greengard

      Pages 357-361

   3. Cyclic AMP-Dependent Protein Phosphorylation

      • J. A. Beavo, M. C. Mumby

      Pages 363-392

   4. Cyclic GMP-Dependent Protein Phosphorylation

      • J. F. Kuo, M. Shoji

      Pages 393-424

   5. Calcium-Dependent Protein Phosphorylation

      • H. Schulman

      Pages 425-478

   6. Photoaffinity Labeling of Cyclic AMP-Dependent and Cyclic GMP-Dependent Protein Kinases

      • U. Walter, P. Greengard

      Pages 479-505

   7. Nuclear Protein Phosphorylation and the Regulation of Gene Expression

      • E. M. Johnson

      Pages 507-533

4. Back Matter

   Pages 535-557

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The purpose of the present volume, the first of two on the pharmacology, biochemistry, and physiology of cyclic nucleotides, is to provide a comprehensive and up-to-date anthology on the nature and role of these important chemical regulators. Each of the chapters is the work of internationally known researchers who present a lucid and detailed review of their subject and not merely a single laboratory's viewpoint. The chapters emphasize critical assessments of the field rather than mere listings of experimental findings. By so doing, the contributors present the role of cyclic nucleotides in relationship to other intracellular regulators. Each chapter begins with a detailed summary to allow the reader to obtain a rapid overview of subsequent material. In addition, there are extensive bibliographies and a detailed subject index. Wherever pertinent, the chapters contain sections on drug mechanisms, physiological relevance, and disease processes. The Volume is divided into two sections, each beginning with an overview written by Professors T. W. RALL and P. GREENGARD, respectively. The first section focuses on the detailed pharmacology and chemistry of cyclic nucleotides, including their formation, degradation, measurement, and interaction with various modulatory agents, such as receptors and calcium. The second section is concerned with the biochemistry of protein phosphorylation, a process which appears to be one of the most important mechanisms for the intracellular expression of cyclic nucleotide action in eukaryotic cells.

• Calcium
• Nucleotide
• biochemistry
• chemistry
• drug
• pharmacology
• phosphorylation
• physiology
• protein
• receptor
• research

• Neuropharmacology Research Laboratory, Departments of Neurology and Pharmacology, Harvard Medical School, Massachusetts General Hospital, Boston, USA

  J. A. Nathanson

• Biochemical Neuropharmacology Unit, NINCDS National Institutes of Health, Bethesda, USA

  J. W. Kebabian

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