Conformation of Biological Molecules

New Results from NMR

  • Girjesh Govil
  • Ramakrishna V. Hosur

Part of the NMR Basic Principles and Progress book series (NMR, volume 20)

Table of contents

  1. Front Matter
    Pages I-VIII
  2. Girjesh Govil, Ramakrishna V. Hosur
    Pages 1-17
  3. Girjesh Govil, Ramakrishna V. Hosur
    Pages 18-38
  4. Girjesh Govil, Ramakrishna V. Hosur
    Pages 39-80
  5. Girjesh Govil, Ramakrishna V. Hosur
    Pages 81-143
  6. Girjesh Govil, Ramakrishna V. Hosur
    Pages 144-154
  7. Girjesh Govil, Ramakrishna V. Hosur
    Pages 155-173
  8. Girjesh Govil, Ramakrishna V. Hosur
    Pages 174-174
  9. Girjesh Govil, Ramakrishna V. Hosur
    Pages 175-199
  10. Girjesh Govil, Ramakrishna V. Hosur
    Pages 200-212
  11. Back Matter
    Pages 213-218

About these proceedings

Introduction

The determination of the three-dimensional structure of a biological molecule is the starting point in the understanding of molecular mechanisms involved in its complex biochemical reactions. The molecular architecture of multimolecular systems such as membranes and chromosomes provides the key to the fascinating field of molecular biology. Stereochemical details of biological macromolecules and their interactions with pharmacological agents form the basis for drug design. Naturally, the study of the structure and function of biological molecules has aroused tremendous interest and investigations in this area are being carried out in a large number of laboratories. The techniques used for this purpose include both experimental methods (X-ray and neutron diffraction measurements, study of NMR, ESR, vibrational and electronic spectra, ORD, CD and dipole moment measurements, biochemical modifications etc. ) and the­ oretical methods (quantum mechanical and classical potential energy calculations, Monte­ Carlo simulations and molecular graphics). F or several years now, X-ray diffraction [1] has served as our only source of infor­ mation on the three-dimensional arrangements of atoms in biopolymers. Fiber-diffrac­ tion of DNA led to the proposal of the DNA double helix. Fibers of long~hain polymers show ordering in the direction of the fibre-axis but not in the transverse plane. Accurate estimates of the dimensions of helical structures can be made using techniques on the basis of which models of biopolymers can be constructed.

Keywords

DNA Molecules Molekularbiologie X-ray biopolymers

Authors and affiliations

  • Girjesh Govil
    • 1
  • Ramakrishna V. Hosur
    • 1
  1. 1.Tata Institute of Fundamental ResearchBombayIndia

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-68097-7
  • Copyright Information Springer-Verlag Berlin Heidelberg 1982
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-68099-1
  • Online ISBN 978-3-642-68097-7
  • Series Print ISSN 0170-5989
  • About this book
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